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Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies

Kristinsson, Sigurdur Y.; Goldin, Lynn R.; Bjorkholm, Magnus; Koshiol, Jill; Turesson, Ingemar LU and Landgren, Ola (2009) In Haematologica 94(11). p.1581-1589
Abstract
There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying... (More)
There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
susceptibility, familial aggregation, multiple myeloma, MGUS, lymphoma, Waldenstrom's macroglobulinemia, lymphoplasmacytic lymphoma, leukemia, chronic lymphocytic, Hodgkin's lymphoma, non-Hodgkin's lymphoma, immune-related, autoimmune disease, rheumatoid arthritis, monoclonal, B-cell lymphocytosis
in
Haematologica
volume
94
issue
11
pages
1581 - 1589
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000272165800015
  • scopus:70449337660
ISSN
1592-8721
DOI
10.3324/haematol.2009.008979
language
English
LU publication?
yes
id
42c05c61-27ba-44a9-a457-2f44ff2ba68b (old id 1517726)
date added to LUP
2010-01-08 11:52:58
date last changed
2017-09-17 06:37:26
@article{42c05c61-27ba-44a9-a457-2f44ff2ba68b,
  abstract     = {There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.},
  author       = {Kristinsson, Sigurdur Y. and Goldin, Lynn R. and Bjorkholm, Magnus and Koshiol, Jill and Turesson, Ingemar and Landgren, Ola},
  issn         = {1592-8721},
  keyword      = {susceptibility,familial aggregation,multiple myeloma,MGUS,lymphoma,Waldenstrom's macroglobulinemia,lymphoplasmacytic lymphoma,leukemia,chronic lymphocytic,Hodgkin's lymphoma,non-Hodgkin's lymphoma,immune-related,autoimmune disease,rheumatoid arthritis,monoclonal,B-cell lymphocytosis},
  language     = {eng},
  number       = {11},
  pages        = {1581--1589},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies},
  url          = {http://dx.doi.org/10.3324/haematol.2009.008979},
  volume       = {94},
  year         = {2009},
}