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Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate

Ali, Syed Muhammad Usman; Nur, Omer; Willander, Magnus and Danielsson, Bengt LU (2009) In IEEE Transactions on Nanotechnology 8(6). p.678-683
Abstract
ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample... (More)
ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MOSFETs, electrochemical devices, Biomedical transducers, biosensor
in
IEEE Transactions on Nanotechnology
volume
8
issue
6
pages
678 - 683
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000272047300003
  • scopus:70749117080
ISSN
1536-125X
DOI
10.1109/TNANO.2009.2019958
language
English
LU publication?
yes
id
3eceea8d-3d7f-4d57-819b-cc86a26bdec1 (old id 1518349)
date added to LUP
2010-01-13 10:59:02
date last changed
2017-11-05 04:06:57
@article{3eceea8d-3d7f-4d57-819b-cc86a26bdec1,
  abstract     = {ZnO nanowires were grown on Ag wire with a diameter of similar to 250 mu m and used in an electrochemical sensor. The enzyme glucose oxidase (GOD) was immobilized on the ZnO nanowires, and the Ag wire was connected directly to the gate of a MOSFET. Upon exposure to glucose (1-100 mu M), the electrochemical response from the GOD induced a stable measurable voltage change on the gate leading to a strong modulation of the current through the MOSFET. For a sensor with uniform ZnO nanowires functionalized with GOD, a fast response time of less than 100 ms was demonstrated. The effect of the uniformity of the ZnO nanowires on the sensing property was also investigated. The extended-gate arrangement facilitated glucose detection in small sample volumes, and made it possible to demonstrate the present sensor concept using a standard low-threshold MOSFET. The extended-gate MOSFET sensor approach demonstrates the possibility and potential of the use of nanostructures coupled to standard electronic components for biosensing applications.},
  author       = {Ali, Syed Muhammad Usman and Nur, Omer and Willander, Magnus and Danielsson, Bengt},
  issn         = {1536-125X},
  keyword      = {MOSFETs,electrochemical devices,Biomedical transducers,biosensor},
  language     = {eng},
  number       = {6},
  pages        = {678--683},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Nanotechnology},
  title        = {Glucose Detection With a Commercial MOSFET Using a ZnO Nanowires Extended Gate},
  url          = {http://dx.doi.org/10.1109/TNANO.2009.2019958},
  volume       = {8},
  year         = {2009},
}