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Increased expression of endothelin ETB and angiotensin AT(1) receptors in peripheral resistance arteries of patients with suspected acute coronary syndrome

Dimitrijevic, Ivan LU ; Ekelund, Ulf LU ; Edvinsson, MarieLouise LU and Edvinsson, Lars LU (2009) In Heart and Vessels 24(6). p.393-398
Abstract
Patients who experience chest pain, in which ischemic heart disease has been ruled out, still have an increased risk of future ischemic cardiac events and premature death, possibly due to subclinical endothelial dysfunction. A feature of endothelial dysfunction is an increased expression of arterial vasoconstrictor endothelin (ET) and angiotensin (AT) receptors. Our aim was to investigate if the arterial expressions of these receptors are changed in patients with suspected but ruled out acute coronary syndrome (ACS). Small subcutaneous arteries (diameter of 100 A mu m) were surgically removed in an abdominal biopsy from 12 patients suspicious of ACS (susp ACS), admitted to the medical telemetry unit for chest pain. The vessels were... (More)
Patients who experience chest pain, in which ischemic heart disease has been ruled out, still have an increased risk of future ischemic cardiac events and premature death, possibly due to subclinical endothelial dysfunction. A feature of endothelial dysfunction is an increased expression of arterial vasoconstrictor endothelin (ET) and angiotensin (AT) receptors. Our aim was to investigate if the arterial expressions of these receptors are changed in patients with suspected but ruled out acute coronary syndrome (ACS). Small subcutaneous arteries (diameter of 100 A mu m) were surgically removed in an abdominal biopsy from 12 patients suspicious of ACS (susp ACS), admitted to the medical telemetry unit for chest pain. The vessels were analyzed for their receptor protein expression by quantitative immunohistochemistry using specific antibodies directed against ETA, ETB, AT(1), and AT(2) receptors. The control group (controls) consisted of eight healthy volunteers matched for age and sex with no previous cardiac illness or medication. The susp ACS group had an increased expression of ETB (by 94%) and AT(1) (by 34%) receptors in the smooth muscle cells of resistance arteries as compared to the control group. There were no significant differences in AT(2) and ETA receptor expression between the groups. The results indicate that the expression of arterial smooth muscle ETB and AT(1) receptors are increased in patients with suspected but ruled out ACS. These receptor changes could be important in the regulation of coronary tone and in the development of atherosclerosis, and may be related to increased cardiovascular risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Immunohistochemistry, Angiotensin, Endothelin, Vasculature, Ischemic heart disease
in
Heart and Vessels
volume
24
issue
6
pages
393 - 398
publisher
Springer
external identifiers
  • wos:000272073400001
  • pmid:20108069
  • scopus:71049188004
ISSN
1615-2573
DOI
10.1007/s00380-008-1136-8
language
English
LU publication?
yes
id
20c87607-5f66-4095-b3b1-992e3d18d77b (old id 1518355)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20108069?dopt=Abstract
date added to LUP
2010-01-13 11:00:52
date last changed
2017-01-15 03:36:05
@article{20c87607-5f66-4095-b3b1-992e3d18d77b,
  abstract     = {Patients who experience chest pain, in which ischemic heart disease has been ruled out, still have an increased risk of future ischemic cardiac events and premature death, possibly due to subclinical endothelial dysfunction. A feature of endothelial dysfunction is an increased expression of arterial vasoconstrictor endothelin (ET) and angiotensin (AT) receptors. Our aim was to investigate if the arterial expressions of these receptors are changed in patients with suspected but ruled out acute coronary syndrome (ACS). Small subcutaneous arteries (diameter of 100 A mu m) were surgically removed in an abdominal biopsy from 12 patients suspicious of ACS (susp ACS), admitted to the medical telemetry unit for chest pain. The vessels were analyzed for their receptor protein expression by quantitative immunohistochemistry using specific antibodies directed against ETA, ETB, AT(1), and AT(2) receptors. The control group (controls) consisted of eight healthy volunteers matched for age and sex with no previous cardiac illness or medication. The susp ACS group had an increased expression of ETB (by 94%) and AT(1) (by 34%) receptors in the smooth muscle cells of resistance arteries as compared to the control group. There were no significant differences in AT(2) and ETA receptor expression between the groups. The results indicate that the expression of arterial smooth muscle ETB and AT(1) receptors are increased in patients with suspected but ruled out ACS. These receptor changes could be important in the regulation of coronary tone and in the development of atherosclerosis, and may be related to increased cardiovascular risk.},
  author       = {Dimitrijevic, Ivan and Ekelund, Ulf and Edvinsson, MarieLouise and Edvinsson, Lars},
  issn         = {1615-2573},
  keyword      = {Immunohistochemistry,Angiotensin,Endothelin,Vasculature,Ischemic heart disease},
  language     = {eng},
  number       = {6},
  pages        = {393--398},
  publisher    = {Springer},
  series       = {Heart and Vessels},
  title        = {Increased expression of endothelin ETB and angiotensin AT(1) receptors in peripheral resistance arteries of patients with suspected acute coronary syndrome},
  url          = {http://dx.doi.org/10.1007/s00380-008-1136-8},
  volume       = {24},
  year         = {2009},
}