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Postexercise Cardiac Performance Among Patients With Mild Primary Hyperparathyroidism

Birgander, Mats; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Willenheimer, Ronnie LU and Rydberg, Erik LU (2009) In The Endocrinologist 19(6). p.263-266
Abstract
Primary hyperparathyroidism (pHPT) is associated with cardiac disease. This prospective study was designed to investigate changes in cardiac function before and after parathyroidectomy. Resting and post exercise cardiac function was compared with matched control subjects. Fifty patients (mean age 62.9 +/- 11 years, 45 women) and 50 healthy control subjects, matched for age and sex were studied. Resting and postmaximum exercise echocardiography/Doppler examination were performed at baseline and 6 months after parathyroidectomy. pHPT patients were tested at baseline and 6 months postoperatively. Control subjects were tested only at baseline. Patients were divided into 4 subgroups based on median preoperative levels of PTH and calcium (Ca):... (More)
Primary hyperparathyroidism (pHPT) is associated with cardiac disease. This prospective study was designed to investigate changes in cardiac function before and after parathyroidectomy. Resting and post exercise cardiac function was compared with matched control subjects. Fifty patients (mean age 62.9 +/- 11 years, 45 women) and 50 healthy control subjects, matched for age and sex were studied. Resting and postmaximum exercise echocardiography/Doppler examination were performed at baseline and 6 months after parathyroidectomy. pHPT patients were tested at baseline and 6 months postoperatively. Control subjects were tested only at baseline. Patients were divided into 4 subgroups based on median preoperative levels of PTH and calcium (Ca): high (up arrow) PTI4/ up arrow Ca, up arrow PTH/low (down arrow) Ca, up arrow Ca/ down arrow PTH, and down arrow PTH/ down arrow Ca. No significant difference between pHPT patients and control subjects regarding post exercise systolic function were detected, There was a tendency of lowed E/A among pHPT patients which was significant in subgroup down arrow PTH/ down arrow Ca (1.07 +/- 0.3). Subgroup up arrow PTH/ up arrow Ca showed a lower S/D compared with control subjects at baseline (1.28 +/- 0.3 vs. 1.48 +/- 0.3, P = 0.029). No significant changes regarding post exercise echocardiographic parameters reflecting cardiac function were detected 6 months after parathyriodectomy. Patients with asymptomatic pHPT showed a tendency of elevated filling pressures and signs of impaired diastolic function during exercise. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diastolic dysfunction, heart function, primary hyperparathyroidism, parathyroidectomy, echocardiography, exercise test
in
The Endocrinologist
volume
19
issue
6
pages
263 - 266
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000271814600008
  • scopus:74549168947
ISSN
1539-9192
DOI
10.1097/TEN.0b013e3181c0478b
language
English
LU publication?
yes
id
ca0ea110-cff3-4233-ab12-8806575f19c3 (old id 1519514)
date added to LUP
2009-12-28 12:16:12
date last changed
2017-01-01 05:12:35
@article{ca0ea110-cff3-4233-ab12-8806575f19c3,
  abstract     = {Primary hyperparathyroidism (pHPT) is associated with cardiac disease. This prospective study was designed to investigate changes in cardiac function before and after parathyroidectomy. Resting and post exercise cardiac function was compared with matched control subjects. Fifty patients (mean age 62.9 +/- 11 years, 45 women) and 50 healthy control subjects, matched for age and sex were studied. Resting and postmaximum exercise echocardiography/Doppler examination were performed at baseline and 6 months after parathyroidectomy. pHPT patients were tested at baseline and 6 months postoperatively. Control subjects were tested only at baseline. Patients were divided into 4 subgroups based on median preoperative levels of PTH and calcium (Ca): high (up arrow) PTI4/ up arrow Ca, up arrow PTH/low (down arrow) Ca, up arrow Ca/ down arrow PTH, and down arrow PTH/ down arrow Ca. No significant difference between pHPT patients and control subjects regarding post exercise systolic function were detected, There was a tendency of lowed E/A among pHPT patients which was significant in subgroup down arrow PTH/ down arrow Ca (1.07 +/- 0.3). Subgroup up arrow PTH/ up arrow Ca showed a lower S/D compared with control subjects at baseline (1.28 +/- 0.3 vs. 1.48 +/- 0.3, P = 0.029). No significant changes regarding post exercise echocardiographic parameters reflecting cardiac function were detected 6 months after parathyriodectomy. Patients with asymptomatic pHPT showed a tendency of elevated filling pressures and signs of impaired diastolic function during exercise.},
  author       = {Birgander, Mats and Bondeson, Anne-Greth and Bondeson, Lennart and Willenheimer, Ronnie and Rydberg, Erik},
  issn         = {1539-9192},
  keyword      = {diastolic dysfunction,heart function,primary hyperparathyroidism,parathyroidectomy,echocardiography,exercise test},
  language     = {eng},
  number       = {6},
  pages        = {263--266},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {The Endocrinologist},
  title        = {Postexercise Cardiac Performance Among Patients With Mild Primary Hyperparathyroidism},
  url          = {http://dx.doi.org/10.1097/TEN.0b013e3181c0478b},
  volume       = {19},
  year         = {2009},
}