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Preserving bone health in patients with hormone-sensitive prostate cancer: the role of bisphosphonates

Saad, Fred; Abrahamsson, Per-Anders LU and Miller, Kurt (2009) In BJU International1999-01-01+01:00 104(11). p.1573-1579
Abstract
Men with prostate cancer initiating androgen-deprivation therapy (ADT) may have multiple factors that threaten their skeletal health, including increased fracture risk from bone loss during ADT and the propensity to develop bone metastases, which may lead to skeletal-related events (SREs). Bisphosphonates have utility in oncology for patients with bone metastases to prevent bone loss during hormonal therapy and in the benign setting to treat osteoporosis. These agents have an emerging role in patients with hormone-sensitive prostate cancer (HSPC). Etidronate, alendronate, pamidronate, and zoledronic acid have all shown efficacy in preventing ADT-related bone loss. Alendronate and zoledronic acid have also been shown to increase bone... (More)
Men with prostate cancer initiating androgen-deprivation therapy (ADT) may have multiple factors that threaten their skeletal health, including increased fracture risk from bone loss during ADT and the propensity to develop bone metastases, which may lead to skeletal-related events (SREs). Bisphosphonates have utility in oncology for patients with bone metastases to prevent bone loss during hormonal therapy and in the benign setting to treat osteoporosis. These agents have an emerging role in patients with hormone-sensitive prostate cancer (HSPC). Etidronate, alendronate, pamidronate, and zoledronic acid have all shown efficacy in preventing ADT-related bone loss. Alendronate and zoledronic acid have also been shown to increase bone mineral density vs baseline during ADT. Patients with bone metastases from HSPC who received 4 mg zoledronic acid every 3 or 4 weeks had a low incidence of skeletal complications, although controlled study data have not been reported. Bisphosphonate treatment in men with HSPC may be effective for the prevention of ADT-related bone loss, underscoring the importance of treating early to avoid SREs and potentially delay disease progression to metastatic bone disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostate cancer, zoledronic acid, bone mineral density, androgen-deprivation therapy, bisphosphonates
in
BJU International1999-01-01+01:00
volume
104
issue
11
pages
1573 - 1579
publisher
Blackwell Science Ltd
external identifiers
  • wos:000271627100006
  • pmid:20053188
  • scopus:70449371295
ISSN
1464-4096
DOI
10.1111/j.1464-410X.2009.08952.x
language
English
LU publication?
yes
id
da3026ee-829e-4ea1-9b5a-672af74a674d (old id 1519615)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20053188?dopt=Abstract
date added to LUP
2009-12-28 11:56:27
date last changed
2017-05-21 03:40:32
@article{da3026ee-829e-4ea1-9b5a-672af74a674d,
  abstract     = {Men with prostate cancer initiating androgen-deprivation therapy (ADT) may have multiple factors that threaten their skeletal health, including increased fracture risk from bone loss during ADT and the propensity to develop bone metastases, which may lead to skeletal-related events (SREs). Bisphosphonates have utility in oncology for patients with bone metastases to prevent bone loss during hormonal therapy and in the benign setting to treat osteoporosis. These agents have an emerging role in patients with hormone-sensitive prostate cancer (HSPC). Etidronate, alendronate, pamidronate, and zoledronic acid have all shown efficacy in preventing ADT-related bone loss. Alendronate and zoledronic acid have also been shown to increase bone mineral density vs baseline during ADT. Patients with bone metastases from HSPC who received 4 mg zoledronic acid every 3 or 4 weeks had a low incidence of skeletal complications, although controlled study data have not been reported. Bisphosphonate treatment in men with HSPC may be effective for the prevention of ADT-related bone loss, underscoring the importance of treating early to avoid SREs and potentially delay disease progression to metastatic bone disease.},
  author       = {Saad, Fred and Abrahamsson, Per-Anders and Miller, Kurt},
  issn         = {1464-4096},
  keyword      = {prostate cancer,zoledronic acid,bone mineral density,androgen-deprivation therapy,bisphosphonates},
  language     = {eng},
  number       = {11},
  pages        = {1573--1579},
  publisher    = {Blackwell Science Ltd},
  series       = {BJU International1999-01-01+01:00},
  title        = {Preserving bone health in patients with hormone-sensitive prostate cancer: the role of bisphosphonates},
  url          = {http://dx.doi.org/10.1111/j.1464-410X.2009.08952.x},
  volume       = {104},
  year         = {2009},
}