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Tridemethylisovelleral, a potent cytotoxic agent

Aujard, Isabelle; Röme, Daniel LU ; Arzel, Erwan; Johansson, Martin H LU ; de Vos, D and Sterner, Olov LU (2005) In Bioorganic & Medicinal Chemistry 13(22). p.6145-6150
Abstract
The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bioorganic & Medicinal Chemistry
volume
13
issue
22
pages
6145 - 6150
publisher
Elsevier
external identifiers
  • pmid:16055337
  • wos:000232733000006
  • scopus:25844441631
ISSN
0968-0896
DOI
10.1016/j.bmc.2005.06.035
language
English
LU publication?
yes
id
2d7772ee-db00-4977-9ae7-5aeb1fcdb1f3 (old id 152305)
date added to LUP
2007-07-10 08:54:30
date last changed
2017-04-30 08:35:50
@article{2d7772ee-db00-4977-9ae7-5aeb1fcdb1f3,
  abstract     = {The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.},
  author       = {Aujard, Isabelle and Röme, Daniel and Arzel, Erwan and Johansson, Martin H and de Vos, D and Sterner, Olov},
  issn         = {0968-0896},
  language     = {eng},
  number       = {22},
  pages        = {6145--6150},
  publisher    = {Elsevier},
  series       = {Bioorganic & Medicinal Chemistry},
  title        = {Tridemethylisovelleral, a potent cytotoxic agent},
  url          = {http://dx.doi.org/10.1016/j.bmc.2005.06.035},
  volume       = {13},
  year         = {2005},
}