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Effect of conditioned stimulus parameters on timing of conditioned purkinje cell responses

Svensson, Pär ; Jirenhed, Dan-Anders LU ; Bengtsson, Fredrik LU and Hesslow, Germund LU (2010) In Journal of Neurophysiology 103(3). p.1329-1336
Abstract
Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) is precisely timed to occur just before the onset of the expected unconditioned stimulus (US). The timing can be changed immediately, however, by varying parameters of the conditioned stimulus (CS). It has previously been shown that increasing the intensity of a peripheral CS or the frequency of a CS consisting of a train of stimuli to the mossy fibers shortens the latency of the CR. The adaptive timing of behavioral CRs probably reflects the timing of an underlying learned inhibitory response in cerebellar Purkinje cells. It is not known how the latency of this Purkinje cell... (More)
Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) is precisely timed to occur just before the onset of the expected unconditioned stimulus (US). The timing can be changed immediately, however, by varying parameters of the conditioned stimulus (CS). It has previously been shown that increasing the intensity of a peripheral CS or the frequency of a CS consisting of a train of stimuli to the mossy fibers shortens the latency of the CR. The adaptive timing of behavioral CRs probably reflects the timing of an underlying learned inhibitory response in cerebellar Purkinje cells. It is not known how the latency of this Purkinje cell CR is controlled. We have recorded form Purkinje cells in conditioned decerebrate ferrets while increasing the intensity of a peripheral CS or the frequency of a mossy fiber CS. We observe changes in the timing of the Purkinje cell CR that match the behavioral effects. The results are consistent with the effect of CS parameters on behavioral CR latency being caused by corresponding changes in Purkinje cell CRs. They suggest that synaptic temporal summation may be one of several mechanisms underlying adaptive timing of movements. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Conditioning, Classical/physiology, Decerebrate State/physiopathology, Electric Stimulation, Electromyography, Electrophysiology, Ferrets/physiology, Forelimb/innervation, Male, Movement/physiology, Nerve Fibers/physiology, Purkinje Cells/physiology
in
Journal of Neurophysiology
volume
103
issue
3
pages
8 pages
publisher
American Physiological Society
external identifiers
  • wos:000275656200017
  • pmid:20032243
  • scopus:77949760837
  • pmid:20032243
ISSN
0022-3077
DOI
10.1152/jn.00524.2009
project
Thinking in Time: Cognition, Communication and Learning
language
English
LU publication?
yes
id
6b5124e2-cf7b-43e7-9fe4-5a037f23a8f4 (old id 1523356)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20032243?dopt=Abstract
date added to LUP
2016-04-04 09:11:30
date last changed
2025-04-04 14:45:37
@article{6b5124e2-cf7b-43e7-9fe4-5a037f23a8f4,
  abstract     = {{Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) is precisely timed to occur just before the onset of the expected unconditioned stimulus (US). The timing can be changed immediately, however, by varying parameters of the conditioned stimulus (CS). It has previously been shown that increasing the intensity of a peripheral CS or the frequency of a CS consisting of a train of stimuli to the mossy fibers shortens the latency of the CR. The adaptive timing of behavioral CRs probably reflects the timing of an underlying learned inhibitory response in cerebellar Purkinje cells. It is not known how the latency of this Purkinje cell CR is controlled. We have recorded form Purkinje cells in conditioned decerebrate ferrets while increasing the intensity of a peripheral CS or the frequency of a mossy fiber CS. We observe changes in the timing of the Purkinje cell CR that match the behavioral effects. The results are consistent with the effect of CS parameters on behavioral CR latency being caused by corresponding changes in Purkinje cell CRs. They suggest that synaptic temporal summation may be one of several mechanisms underlying adaptive timing of movements.}},
  author       = {{Svensson, Pär and Jirenhed, Dan-Anders and Bengtsson, Fredrik and Hesslow, Germund}},
  issn         = {{0022-3077}},
  keywords     = {{Animals; Conditioning, Classical/physiology; Decerebrate State/physiopathology; Electric Stimulation; Electromyography; Electrophysiology; Ferrets/physiology; Forelimb/innervation; Male; Movement/physiology; Nerve Fibers/physiology; Purkinje Cells/physiology}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1329--1336}},
  publisher    = {{American Physiological Society}},
  series       = {{Journal of Neurophysiology}},
  title        = {{Effect of conditioned stimulus parameters on timing of conditioned purkinje cell responses}},
  url          = {{http://dx.doi.org/10.1152/jn.00524.2009}},
  doi          = {{10.1152/jn.00524.2009}},
  volume       = {{103}},
  year         = {{2010}},
}