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SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Appendino, G; Prosperini, S; Valdivia, Carola LU ; Ballero, M; Colombano, G; Billington, R A; Genazzani, A A and Sterner, Olov LU (2005) In Journal of Natural Products 68(8). p.1213-1217
Abstract
An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Natural Products
volume
68
issue
8
pages
1213 - 1217
publisher
The American Chemical Society
external identifiers
  • pmid:16124763
  • wos:000231578000014
  • scopus:24744471405
ISSN
0163-3864
DOI
10.1021/np050115m
language
English
LU publication?
yes
id
6ae10736-4a0d-44fa-926b-2eac5489e690 (old id 152347)
date added to LUP
2007-07-10 08:31:08
date last changed
2017-09-10 04:36:26
@article{6ae10736-4a0d-44fa-926b-2eac5489e690,
  abstract     = {An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.},
  author       = {Appendino, G and Prosperini, S and Valdivia, Carola and Ballero, M and Colombano, G and Billington, R A and Genazzani, A A and Sterner, Olov},
  issn         = {0163-3864},
  language     = {eng},
  number       = {8},
  pages        = {1213--1217},
  publisher    = {The American Chemical Society},
  series       = {Journal of Natural Products},
  title        = {SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis},
  url          = {http://dx.doi.org/10.1021/np050115m},
  volume       = {68},
  year         = {2005},
}