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Influence of salt ions on binding to molecularly imprinted polymers.

Kempe, Henrik LU and Kempe, Maria LU (2010) In Analytical and Bioanalytical Chemistry 396(4). p.1599-1606
Abstract
Salt ions were found to have an influence on template binding to two model molecularly imprinted polymers (MIPs), targeted to penicillin G and propranolol, respectively, in water-acetonitrile mixtures. Water was detrimental to rebinding of penicillin G whereas propranolol bound in the entire water-acetonitrile range tested. In 100% aqueous solution, 3-M salt solutions augmented the binding of both templates. The effects followed the Hofmeister series with kosmotropic ions promoting the largest increase. Binding was mainly of a non-specific nature under these conditions. In acetonitrile containing low amounts of water, the specific binding to the MIPs increased with the addition of salts. Binding of penicillin G followed the Hofmeister... (More)
Salt ions were found to have an influence on template binding to two model molecularly imprinted polymers (MIPs), targeted to penicillin G and propranolol, respectively, in water-acetonitrile mixtures. Water was detrimental to rebinding of penicillin G whereas propranolol bound in the entire water-acetonitrile range tested. In 100% aqueous solution, 3-M salt solutions augmented the binding of both templates. The effects followed the Hofmeister series with kosmotropic ions promoting the largest increase. Binding was mainly of a non-specific nature under these conditions. In acetonitrile containing low amounts of water, the specific binding to the MIPs increased with the addition of salts. Binding of penicillin G followed the Hofmeister series while an ion-exchange mechanism was observed for propranolol. The results suggest that hydration of kosmotropic ions reduces the water activity in water-poor media providing a stabilizing effect on water-sensitive MIP-template interactions. The effects were utilized to develop a procedure for molecularly imprinted solid-phase extraction (MISPE) of penicillin G from milk with a recovery of 87%. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical and Bioanalytical Chemistry
volume
396
issue
4
pages
1599 - 1606
publisher
Springer
external identifiers
  • wos:000274140500023
  • pmid:20012741
  • scopus:76749172187
ISSN
1618-2642
DOI
10.1007/s00216-009-3329-0
language
English
LU publication?
yes
id
a2312226-1f92-470a-a2c9-cfac316fe60c (old id 1523582)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20012741?dopt=Abstract
date added to LUP
2010-01-15 10:06:41
date last changed
2018-05-29 10:44:29
@article{a2312226-1f92-470a-a2c9-cfac316fe60c,
  abstract     = {Salt ions were found to have an influence on template binding to two model molecularly imprinted polymers (MIPs), targeted to penicillin G and propranolol, respectively, in water-acetonitrile mixtures. Water was detrimental to rebinding of penicillin G whereas propranolol bound in the entire water-acetonitrile range tested. In 100% aqueous solution, 3-M salt solutions augmented the binding of both templates. The effects followed the Hofmeister series with kosmotropic ions promoting the largest increase. Binding was mainly of a non-specific nature under these conditions. In acetonitrile containing low amounts of water, the specific binding to the MIPs increased with the addition of salts. Binding of penicillin G followed the Hofmeister series while an ion-exchange mechanism was observed for propranolol. The results suggest that hydration of kosmotropic ions reduces the water activity in water-poor media providing a stabilizing effect on water-sensitive MIP-template interactions. The effects were utilized to develop a procedure for molecularly imprinted solid-phase extraction (MISPE) of penicillin G from milk with a recovery of 87%.},
  author       = {Kempe, Henrik and Kempe, Maria},
  issn         = {1618-2642},
  language     = {eng},
  number       = {4},
  pages        = {1599--1606},
  publisher    = {Springer},
  series       = {Analytical and Bioanalytical Chemistry},
  title        = {Influence of salt ions on binding to molecularly imprinted polymers.},
  url          = {http://dx.doi.org/10.1007/s00216-009-3329-0},
  volume       = {396},
  year         = {2010},
}