Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca
(2005) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 60c(5-6). p.478-484- Abstract
- In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be... (More)
- In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/152379
- author
- Rether, J ; Erkel, G ; Sterner, Olov LU and Anke, T
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
- volume
- 60c
- issue
- 5-6
- pages
- 478 - 484
- publisher
- Verlag der Zeitschrift für Naturforschung
- external identifiers
-
- wos:000231101200017
- scopus:22144440946
- ISSN
- 0939-5075
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 9641ee16-0ac3-4da0-81ee-d9a8f7c155e7 (old id 152379)
- alternative location
- http://www.znaturforsch.com/ac/v60c/60c0478.pdf
- http://www.znaturforsch.com/ac/v60c/c60c.htm#No5
- date added to LUP
- 2016-04-01 17:15:30
- date last changed
- 2022-01-29 01:27:58
@article{9641ee16-0ac3-4da0-81ee-d9a8f7c155e7, abstract = {{In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound.}}, author = {{Rether, J and Erkel, G and Sterner, Olov and Anke, T}}, issn = {{0939-5075}}, language = {{eng}}, number = {{5-6}}, pages = {{478--484}}, publisher = {{Verlag der Zeitschrift für Naturforschung}}, series = {{Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences}}, title = {{Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca}}, url = {{http://www.znaturforsch.com/ac/v60c/60c0478.pdf}}, volume = {{60c}}, year = {{2005}}, }