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Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca

Rether, J; Erkel, G; Sterner, Olov LU and Anke, T (2005) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 60c(5-6). p.478-484
Abstract
In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be... (More)
In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound. (Less)
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Contribution to journal
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published
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in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
60c
issue
5-6
pages
478 - 484
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000231101200017
  • scopus:22144440946
ISSN
0939-5075
language
English
LU publication?
yes
id
9641ee16-0ac3-4da0-81ee-d9a8f7c155e7 (old id 152379)
alternative location
http://www.znaturforsch.com/ac/v60c/60c0478.pdf
http://www.znaturforsch.com/ac/v60c/c60c.htm#No5
date added to LUP
2007-07-10 14:06:12
date last changed
2017-01-01 07:28:41
@article{9641ee16-0ac3-4da0-81ee-d9a8f7c155e7,
  abstract     = {In a search for inhibitors of the inducible tumor necrosis factor-alpha (TNF-alpha) promoter activity and synthesis, a new chlorinated cyclopentenone was isolated from fermentations of the ascomycete Mollisia melaleuca. The structure was determined by a combination of spectroscopic techniques. The compound blocked the inducible human TNF-alpha promoter activity and synthesis with IC50-values of 2.5-5 mu g/ml (8.1-16.1 mu M). Studies on the mode of action of the compound revealed that the inhibition of TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the I kappa B protein which prevents the activation of the transcription factor NF-kappa B. No cytotoxic, antibacterial and antifungal activities could be observed up to 100 mu g/ml (323 mu m) of the compound.},
  author       = {Rether, J and Erkel, G and Sterner, Olov and Anke, T},
  issn         = {0939-5075},
  language     = {eng},
  number       = {5-6},
  pages        = {478--484},
  publisher    = {Verlag der Zeitschrift für Naturforschung},
  series       = {Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences},
  title        = {Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca},
  volume       = {60c},
  year         = {2005},
}