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Production of sordarin and related metabolites by the coprophilous fungus Podospora pleiospora in submerged culture and in its natural substrate

Weber, R W S; Meffert, A; Anke, H and Sterner, Olov LU (2005) In Mycological Research 109(5). p.619-626
Abstract
Rabbit pellets collected from the field were colonized by Podospora pleiospora at the exclusion of other coprophilous fungi, suggesting antibiosis. in liquid culture, P. pleiospora produced sordarin (1); sordarin B (2), a new compound in which sordarose is replaced by rhamnose, hydroxysordarin (3); and sordaricin (4). The major compounds I and 2 exhibited minimum inhibitory concentrations of 0.5-2.5 mu g ml(-1) against the yeasts Nematospora coryli and Sporobolomyces roseus, but showed little or no activity against bacteria or coprophilous filamentous fungi. In liquid culture, the production of 1 and 2 together amounted to 2.7 mu g ml(-1), whereas in rabbit dung only 1 was produced at a similar concentration (2.3 mu g g(-1) fresh weight).... (More)
Rabbit pellets collected from the field were colonized by Podospora pleiospora at the exclusion of other coprophilous fungi, suggesting antibiosis. in liquid culture, P. pleiospora produced sordarin (1); sordarin B (2), a new compound in which sordarose is replaced by rhamnose, hydroxysordarin (3); and sordaricin (4). The major compounds I and 2 exhibited minimum inhibitory concentrations of 0.5-2.5 mu g ml(-1) against the yeasts Nematospora coryli and Sporobolomyces roseus, but showed little or no activity against bacteria or coprophilous filamentous fungi. In liquid culture, the production of 1 and 2 together amounted to 2.7 mu g ml(-1), whereas in rabbit dung only 1 was produced at a similar concentration (2.3 mu g g(-1) fresh weight). The biosynthesis of these substances was unaffected by the presence of inoculum of other fungi tested (Sporoholomyces roseus or Penicillium claviforme) in liquid culture or on dung. Sordarin-type natural products are therefore synthesized by P. pleiospora at sufficiently high concentrations to account for antibiosis against yeasts, but not against filamentous fungi. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mycological Research
volume
109
issue
5
pages
619 - 626
publisher
Cambridge University Press
external identifiers
  • wos:000230007300011
  • pmid:16018317
  • scopus:20744433856
ISSN
1469-8102
DOI
10.1017/S0953756205002765
language
English
LU publication?
yes
id
73202b5e-1f34-4277-a314-09e95275fc5e (old id 152392)
date added to LUP
2007-07-10 15:50:44
date last changed
2017-01-01 04:45:21
@article{73202b5e-1f34-4277-a314-09e95275fc5e,
  abstract     = {Rabbit pellets collected from the field were colonized by Podospora pleiospora at the exclusion of other coprophilous fungi, suggesting antibiosis. in liquid culture, P. pleiospora produced sordarin (1); sordarin B (2), a new compound in which sordarose is replaced by rhamnose, hydroxysordarin (3); and sordaricin (4). The major compounds I and 2 exhibited minimum inhibitory concentrations of 0.5-2.5 mu g ml(-1) against the yeasts Nematospora coryli and Sporobolomyces roseus, but showed little or no activity against bacteria or coprophilous filamentous fungi. In liquid culture, the production of 1 and 2 together amounted to 2.7 mu g ml(-1), whereas in rabbit dung only 1 was produced at a similar concentration (2.3 mu g g(-1) fresh weight). The biosynthesis of these substances was unaffected by the presence of inoculum of other fungi tested (Sporoholomyces roseus or Penicillium claviforme) in liquid culture or on dung. Sordarin-type natural products are therefore synthesized by P. pleiospora at sufficiently high concentrations to account for antibiosis against yeasts, but not against filamentous fungi.},
  author       = {Weber, R W S and Meffert, A and Anke, H and Sterner, Olov},
  issn         = {1469-8102},
  language     = {eng},
  number       = {5},
  pages        = {619--626},
  publisher    = {Cambridge University Press},
  series       = {Mycological Research},
  title        = {Production of sordarin and related metabolites by the coprophilous fungus Podospora pleiospora in submerged culture and in its natural substrate},
  url          = {http://dx.doi.org/10.1017/S0953756205002765},
  volume       = {109},
  year         = {2005},
}