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Molecularly imprinted polymer thin films on quartz crystal microbalance using a surface bound photo-radical initiator

Piacham, Theeraphon LU ; Josell, Åsa LU ; Arwin, H; Prachayasittikul, V and Ye, Lei LU (2005) In Analytica Chimica Acta 536(1-2). p.191-196
Abstract
The present work aims to study preparation of thin MIP films on a gold-coated QCM resonator in a well-controlled and reproducible manner. A surface-bound photo-radical initiator was used to furnish an imprinting polymerization in a dilute solution of template, functional monomer and crosslinker. Prior to polymerization, the photo-initiator was covalently coupled to a self-assembled monolayer of carboxyl terminated alkanethiol on a gold surface. With this approach we were able to control the thickness of the MIP film to be below 50 nm, where the selective recognition of target analytes can be easily detected by the underlying quartz crystal resonator. When used in a flow injection analysis system, the assembled QCM sensor generated a large... (More)
The present work aims to study preparation of thin MIP films on a gold-coated QCM resonator in a well-controlled and reproducible manner. A surface-bound photo-radical initiator was used to furnish an imprinting polymerization in a dilute solution of template, functional monomer and crosslinker. Prior to polymerization, the photo-initiator was covalently coupled to a self-assembled monolayer of carboxyl terminated alkanethiol on a gold surface. With this approach we were able to control the thickness of the MIP film to be below 50 nm, where the selective recognition of target analytes can be easily detected by the underlying quartz crystal resonator. When used in a flow injection analysis system, the assembled QCM sensor generated a large frequency change (> 30Hz) upon encountering a small amount of analyte (0.19 mM). The sensor had a very short response time (< 1 min), and displayed certain chiral selectivity towards the original template, (S)-propranolol at a concentration higher than 0.38 mM in aqueous solution. (c) 2004 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytica Chimica Acta
volume
536
issue
1-2
pages
191 - 196
publisher
Elsevier
external identifiers
  • wos:000228673300023
  • scopus:17144402906
ISSN
1873-4324
DOI
10.1016/j.aca.2004.12.067
language
English
LU publication?
yes
id
9dba62b0-f4a9-4fea-b362-0b280dd99686 (old id 152640)
date added to LUP
2007-07-16 11:22:32
date last changed
2017-03-19 04:08:39
@article{9dba62b0-f4a9-4fea-b362-0b280dd99686,
  abstract     = {The present work aims to study preparation of thin MIP films on a gold-coated QCM resonator in a well-controlled and reproducible manner. A surface-bound photo-radical initiator was used to furnish an imprinting polymerization in a dilute solution of template, functional monomer and crosslinker. Prior to polymerization, the photo-initiator was covalently coupled to a self-assembled monolayer of carboxyl terminated alkanethiol on a gold surface. With this approach we were able to control the thickness of the MIP film to be below 50 nm, where the selective recognition of target analytes can be easily detected by the underlying quartz crystal resonator. When used in a flow injection analysis system, the assembled QCM sensor generated a large frequency change (&gt; 30Hz) upon encountering a small amount of analyte (0.19 mM). The sensor had a very short response time (&lt; 1 min), and displayed certain chiral selectivity towards the original template, (S)-propranolol at a concentration higher than 0.38 mM in aqueous solution. (c) 2004 Elsevier B.V. All rights reserved.},
  author       = {Piacham, Theeraphon and Josell, Åsa and Arwin, H and Prachayasittikul, V and Ye, Lei},
  issn         = {1873-4324},
  language     = {eng},
  number       = {1-2},
  pages        = {191--196},
  publisher    = {Elsevier},
  series       = {Analytica Chimica Acta},
  title        = {Molecularly imprinted polymer thin films on quartz crystal microbalance using a surface bound photo-radical initiator},
  url          = {http://dx.doi.org/10.1016/j.aca.2004.12.067},
  volume       = {536},
  year         = {2005},
}