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Enhanced protein adsorption due to charge regulation

Lund, Mikael LU orcid ; Åkesson, Torbjörn LU and Jönsson, Bo LU (2005) In Langmuir 21(18). p.8385-8388
Abstract
When a protein molecule approaches a charged surface, its protonation state can undergo dramatic changes due to the imposed electric potential. This has a large impact on adsorption strengths that may be enhanced by several kT. Using mesoscopic simulation techniques as well as analytical theories, we have investigated this regulation mechanism and demonstrate how it is influenced by salt concentration and solution pH. Using hisactophilin as a test case, we show how the binding to a lipid membrane is governed by small changes in pH and that this is intimately coupled to the charge regulation mechanism.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
21
issue
18
pages
8385 - 8388
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000231550000044
  • scopus:24944550836
ISSN
0743-7463
DOI
10.1021/la050607z
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)
id
b9508064-e415-49da-bcdc-7e04a5be6620 (old id 152706)
date added to LUP
2016-04-01 11:51:01
date last changed
2021-07-13 05:18:09
@article{b9508064-e415-49da-bcdc-7e04a5be6620,
  abstract     = {When a protein molecule approaches a charged surface, its protonation state can undergo dramatic changes due to the imposed electric potential. This has a large impact on adsorption strengths that may be enhanced by several kT. Using mesoscopic simulation techniques as well as analytical theories, we have investigated this regulation mechanism and demonstrate how it is influenced by salt concentration and solution pH. Using hisactophilin as a test case, we show how the binding to a lipid membrane is governed by small changes in pH and that this is intimately coupled to the charge regulation mechanism.},
  author       = {Lund, Mikael and Åkesson, Torbjörn and Jönsson, Bo},
  issn         = {0743-7463},
  language     = {eng},
  number       = {18},
  pages        = {8385--8388},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Langmuir},
  title        = {Enhanced protein adsorption due to charge regulation},
  url          = {http://dx.doi.org/10.1021/la050607z},
  doi          = {10.1021/la050607z},
  volume       = {21},
  year         = {2005},
}