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Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?

Norval, Mary; Björn, Lars Olof LU and de Gruijl, Frank R. (2010) In Photochemical and Photobiological Sciences 9(1). p.11-17
Abstract
The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D3 in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
previtamin D, ultraviolet radiation, action spectrum, vitamin D
in
Photochemical and Photobiological Sciences
volume
9
issue
1
pages
11 - 17
publisher
Royal Society of Chemistry
external identifiers
  • wos:000273339100002
  • scopus:74049133208
ISSN
1474-9092
DOI
10.1039/b9pp00012g
project
Photobiology
language
English
LU publication?
yes
id
e06b618e-2501-4de0-a462-e7276319850a (old id 1528766)
date added to LUP
2010-02-10 12:28:22
date last changed
2018-06-24 03:05:49
@article{e06b618e-2501-4de0-a462-e7276319850a,
  abstract     = {The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D3 in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.},
  author       = {Norval, Mary and Björn, Lars Olof and de Gruijl, Frank R.},
  issn         = {1474-9092},
  keyword      = {previtamin D,ultraviolet radiation,action spectrum,vitamin D},
  language     = {eng},
  number       = {1},
  pages        = {11--17},
  publisher    = {Royal Society of Chemistry},
  series       = {Photochemical and Photobiological Sciences},
  title        = {Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?},
  url          = {http://dx.doi.org/10.1039/b9pp00012g},
  volume       = {9},
  year         = {2010},
}