Advanced

Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?

Kölbel, Tilo LU ; Donath, Tobias; Strandberg, Karin LU ; Flondell-Sité, Despina LU ; Kuhme, Tobias; Gottsäter, Anders LU and Lindblad, Bengt LU (2010) In Angiology 61(1). p.113-118
Abstract
Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10... (More)
Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aneurysm thrombus, thrombin activation, abdominal aortic aneurysm, coagulation activation
in
Angiology
volume
61
issue
1
pages
113 - 118
publisher
SAGE Publications Inc.
external identifiers
  • wos:000273095600019
  • scopus:73449138761
ISSN
0003-3197
DOI
10.1177/0003319709335906
language
English
LU publication?
yes
id
19b8abd9-4625-4788-bf9b-45255fb01671 (old id 1535552)
date added to LUP
2010-01-27 11:47:07
date last changed
2018-07-01 03:57:35
@article{19b8abd9-4625-4788-bf9b-45255fb01671,
  abstract     = {Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P &lt; .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA.},
  author       = {Kölbel, Tilo and Donath, Tobias and Strandberg, Karin and Flondell-Sité, Despina and Kuhme, Tobias and Gottsäter, Anders and Lindblad, Bengt},
  issn         = {0003-3197},
  keyword      = {aneurysm thrombus,thrombin activation,abdominal aortic aneurysm,coagulation activation},
  language     = {eng},
  number       = {1},
  pages        = {113--118},
  publisher    = {SAGE Publications Inc.},
  series       = {Angiology},
  title        = {Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?},
  url          = {http://dx.doi.org/10.1177/0003319709335906},
  volume       = {61},
  year         = {2010},
}