Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?
(2010) In Angiology 61(1). p.113-118- Abstract
- Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10... (More)
- Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1535552
- author
- Kölbel, Tilo LU ; Donath, Tobias ; Strandberg, Karin LU ; Flondell-Sité, Despina LU ; Kuhme, Tobias ; Gottsäter, Anders LU and Lindblad, Bengt LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Abdominal aortic aneurysm, Aneurysm thrombus, Coagulation activation, Thrombin activation
- in
- Angiology
- volume
- 61
- issue
- 1
- pages
- 6 pages
- publisher
- SAGE Publications
- external identifiers
-
- wos:000273095600019
- scopus:73449138761
- pmid:19625264
- ISSN
- 0003-3197
- DOI
- 10.1177/0003319709335906
- language
- English
- LU publication?
- yes
- id
- 19b8abd9-4625-4788-bf9b-45255fb01671 (old id 1535552)
- date added to LUP
- 2016-04-01 14:09:47
- date last changed
- 2024-02-12 08:17:17
@article{19b8abd9-4625-4788-bf9b-45255fb01671, abstract = {{Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA.}}, author = {{Kölbel, Tilo and Donath, Tobias and Strandberg, Karin and Flondell-Sité, Despina and Kuhme, Tobias and Gottsäter, Anders and Lindblad, Bengt}}, issn = {{0003-3197}}, keywords = {{Abdominal aortic aneurysm; Aneurysm thrombus; Coagulation activation; Thrombin activation}}, language = {{eng}}, number = {{1}}, pages = {{113--118}}, publisher = {{SAGE Publications}}, series = {{Angiology}}, title = {{Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?}}, url = {{http://dx.doi.org/10.1177/0003319709335906}}, doi = {{10.1177/0003319709335906}}, volume = {{61}}, year = {{2010}}, }