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Serum levels of vitamin D, PTH, calcium and breast cancer risk - a prospective nested case-control study.

Almquist, Martin LU ; Bondeson, Anne-Greth LU ; Bondeson, Lennart LU ; Malm, Johan LU and Manjer, Jonas LU (2010) In International Journal of Cancer 127(9). p.2159-2168
Abstract
Previous studies indicate that calcium and its regulating hormones, i.e. parathyroid hormone (PTH) and vitamin D, might affect breast cancer risk. Evidence also suggests that this relationship could be influenced by menopausal status and BMI. We examined breast cancer risk related to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH and calcium using a nested case-control design within the Malmö Diet and Cancer Study. There were 764 incident breast cancer cases, and 764 controls were selected by incidence density matching, using age as the underlying time scale, matching on calendar time at inclusion, menopausal status and age at inclusion. Using logistic regression analysis, odds ratios (OR) with 95% confidence... (More)
Previous studies indicate that calcium and its regulating hormones, i.e. parathyroid hormone (PTH) and vitamin D, might affect breast cancer risk. Evidence also suggests that this relationship could be influenced by menopausal status and BMI. We examined breast cancer risk related to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH and calcium using a nested case-control design within the Malmö Diet and Cancer Study. There were 764 incident breast cancer cases, and 764 controls were selected by incidence density matching, using age as the underlying time scale, matching on calendar time at inclusion, menopausal status and age at inclusion. Using logistic regression analysis, odds ratios (OR) with 95% confidence intervals were calculated for breast cancer risk in different quartiles of the analysed factors. All analyses were adjusted for risk factors for breast cancer, and for levels of albumin, creatinine and phosphate. Analyses were repeated stratified for BMI and menopausal status, and for low vs. high levels of 25OHD(3), PTH and calcium. There was a weak, non-significant inverse association between breast cancer risk and 25OHD(3), and the OR for the 2(nd), 3(rd) and 4(th) quartiles, as compared to the first, were 0.84(0.60-1.15), 0.84(0.60-1.17), and 0.93(0.66-1.33). Serum calcium was positively associated with breast cancer in pre-menopausal women (OR for the 4(th) quartile = 3.10:1.33-7.22 and p for quartile trend=0.04), and in women with BMI>25 (OR for the 4(th) quartile=1.94:1.12-3.37 and p for trend<0.01). There was no association between baseline serum PTH and breast cancer risk. (c) 2010 UICC. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calcium, BMI, parathyroid hormone, breast cancer, vitamin D
in
International Journal of Cancer
volume
127
issue
9
pages
2159 - 2168
publisher
John Wiley & Sons
external identifiers
  • wos:000282539600017
  • pmid:20112341
  • scopus:77956641349
ISSN
0020-7136
DOI
10.1002/ijc.25215
language
English
LU publication?
yes
id
1a067928-d9cc-44d6-8609-3a02ce1ea49d (old id 1540467)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20112341?dopt=Abstract
date added to LUP
2010-02-03 11:05:37
date last changed
2018-06-24 03:01:00
@article{1a067928-d9cc-44d6-8609-3a02ce1ea49d,
  abstract     = {Previous studies indicate that calcium and its regulating hormones, i.e. parathyroid hormone (PTH) and vitamin D, might affect breast cancer risk. Evidence also suggests that this relationship could be influenced by menopausal status and BMI. We examined breast cancer risk related to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH and calcium using a nested case-control design within the Malmö Diet and Cancer Study. There were 764 incident breast cancer cases, and 764 controls were selected by incidence density matching, using age as the underlying time scale, matching on calendar time at inclusion, menopausal status and age at inclusion. Using logistic regression analysis, odds ratios (OR) with 95% confidence intervals were calculated for breast cancer risk in different quartiles of the analysed factors. All analyses were adjusted for risk factors for breast cancer, and for levels of albumin, creatinine and phosphate. Analyses were repeated stratified for BMI and menopausal status, and for low vs. high levels of 25OHD(3), PTH and calcium. There was a weak, non-significant inverse association between breast cancer risk and 25OHD(3), and the OR for the 2(nd), 3(rd) and 4(th) quartiles, as compared to the first, were 0.84(0.60-1.15), 0.84(0.60-1.17), and 0.93(0.66-1.33). Serum calcium was positively associated with breast cancer in pre-menopausal women (OR for the 4(th) quartile = 3.10:1.33-7.22 and p for quartile trend=0.04), and in women with BMI&gt;25 (OR for the 4(th) quartile=1.94:1.12-3.37 and p for trend&lt;0.01). There was no association between baseline serum PTH and breast cancer risk. (c) 2010 UICC.},
  author       = {Almquist, Martin and Bondeson, Anne-Greth and Bondeson, Lennart and Malm, Johan and Manjer, Jonas},
  issn         = {0020-7136},
  keyword      = {calcium,BMI,parathyroid hormone,breast cancer,vitamin D},
  language     = {eng},
  number       = {9},
  pages        = {2159--2168},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Serum levels of vitamin D, PTH, calcium and breast cancer risk - a prospective nested case-control study.},
  url          = {http://dx.doi.org/10.1002/ijc.25215},
  volume       = {127},
  year         = {2010},
}