Platelet Monoamine Oxidase B Activity Did Not Predict Destructive Personality Traits or Violent Recidivism: A Prospective Study in Male Forensic Psychiatric Examinees.
(2010) In Neuropsychobiology 61(2). p.87-96- Abstract
- Aims: This prospective study was designed to replicate previous findings of an association between the platelet monoamine oxidase B (MAO-B) activity and factors of relevance for criminal behaviour in a well-documented clinical study population. Methods: Subjects (n = 77, aged 17-76 years, median 30 years) were recruited among consecutive perpetrators of severe interpersonal violent and/or sexual crimes referred to forensic psychiatric investigation. Participants were extensively investigated by structured psychiatric, psychological and social workups, including state-of-the-art rating instruments and official records, and with laboratory tests including venous blood sampling for determination of MAO-B activity. A subset of 36 individuals... (More)
- Aims: This prospective study was designed to replicate previous findings of an association between the platelet monoamine oxidase B (MAO-B) activity and factors of relevance for criminal behaviour in a well-documented clinical study population. Methods: Subjects (n = 77, aged 17-76 years, median 30 years) were recruited among consecutive perpetrators of severe interpersonal violent and/or sexual crimes referred to forensic psychiatric investigation. Participants were extensively investigated by structured psychiatric, psychological and social workups, including state-of-the-art rating instruments and official records, and with laboratory tests including venous blood sampling for determination of MAO-B activity. A subset of 36 individuals had lumbar punctures to measure cerebrospinal fluid concentrations of monoamine neurotransmitter metabolites. Results: Platelet MAO-B activity did not show any significant correlation with assessments of childhood behavioural disorders, substance abuse, or psychosocial adversity, nor with any crime-related factors, such as scores on the Life History of Aggression Scale, the Psychopathy Checklist or recidivistic violent crime. No significant correlation was found between MAO-B and any of the monoamine metabolites. Analyses in subgroups of smokers/non-smokers did not change this overall result. Conclusions: The findings of the present study did not support the use of MAO-B as a biological marker for aggression-related personality traits or as a predictor for violent recidivism among violent offenders. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1540730
- author
- Gustavson, Christina LU ; Wass, Caroline ; Mansson, Jan-Eric ; Blennow, Kaj ; Forsman, Anders ; Anckarsäter, Henrik LU and Nilsson, Thomas
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuropsychobiology
- volume
- 61
- issue
- 2
- pages
- 87 - 96
- publisher
- Karger
- external identifiers
-
- wos:000273777000005
- pmid:20090378
- scopus:74249087491
- ISSN
- 0302-282X
- DOI
- 10.1159/000275820
- language
- English
- LU publication?
- yes
- id
- ddf9ecfd-d66d-4989-855b-918d4a3b25e7 (old id 1540730)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20090378?dopt=Abstract
- date added to LUP
- 2016-04-04 07:55:56
- date last changed
- 2022-01-29 02:49:05
@article{ddf9ecfd-d66d-4989-855b-918d4a3b25e7,
abstract = {{Aims: This prospective study was designed to replicate previous findings of an association between the platelet monoamine oxidase B (MAO-B) activity and factors of relevance for criminal behaviour in a well-documented clinical study population. Methods: Subjects (n = 77, aged 17-76 years, median 30 years) were recruited among consecutive perpetrators of severe interpersonal violent and/or sexual crimes referred to forensic psychiatric investigation. Participants were extensively investigated by structured psychiatric, psychological and social workups, including state-of-the-art rating instruments and official records, and with laboratory tests including venous blood sampling for determination of MAO-B activity. A subset of 36 individuals had lumbar punctures to measure cerebrospinal fluid concentrations of monoamine neurotransmitter metabolites. Results: Platelet MAO-B activity did not show any significant correlation with assessments of childhood behavioural disorders, substance abuse, or psychosocial adversity, nor with any crime-related factors, such as scores on the Life History of Aggression Scale, the Psychopathy Checklist or recidivistic violent crime. No significant correlation was found between MAO-B and any of the monoamine metabolites. Analyses in subgroups of smokers/non-smokers did not change this overall result. Conclusions: The findings of the present study did not support the use of MAO-B as a biological marker for aggression-related personality traits or as a predictor for violent recidivism among violent offenders.}},
author = {{Gustavson, Christina and Wass, Caroline and Mansson, Jan-Eric and Blennow, Kaj and Forsman, Anders and Anckarsäter, Henrik and Nilsson, Thomas}},
issn = {{0302-282X}},
language = {{eng}},
number = {{2}},
pages = {{87--96}},
publisher = {{Karger}},
series = {{Neuropsychobiology}},
title = {{Platelet Monoamine Oxidase B Activity Did Not Predict Destructive Personality Traits or Violent Recidivism: A Prospective Study in Male Forensic Psychiatric Examinees.}},
url = {{http://dx.doi.org/10.1159/000275820}},
doi = {{10.1159/000275820}},
volume = {{61}},
year = {{2010}},
}