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Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.

Styring, Emelie LU ; Fernebro, Josefin LU ; Jönsson, Per-Ebbe LU ; Ehinger, Anna LU orcid ; Engellau, Jacob LU ; Rissler, Pehr LU ; Rydholm, Anders LU ; Nilbert, Mef LU and Vult von Steyern, Fredrik LU (2010) In Breast Cancer Research and Treatment 122. p.883-887
Abstract
Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of 71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females... (More)
Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of 71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females treated by segmental resection, anti-hormonal treatment and radiotherapy 1980-2005 developed angiosarcomas in the irradiated field on the thoracic wall after median 7.3 years. The clinical presentations were heterogeneous and included hematoma-like lesions, multiple bluish-reddish nodules, and asymptomatic lumps. The overall 5-year survival was 16%. In this population-based cohort, the early angiosarcomas developed in edematous arms after radical mastectomies, whereas more recent cases occurred after a shorter time period in the irradiated fields following breast conserving surgery. We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Breast Cancer Research and Treatment
volume
122
pages
883 - 887
publisher
Springer
external identifiers
  • wos:000280062600029
  • pmid:20087653
  • scopus:77955558896
  • pmid:20087653
ISSN
1573-7217
DOI
10.1007/s10549-009-0703-8
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oncology, MV (013035000), Surgery Research Unit (013242220), Pathology, (Lund) (013030000), Department of Orthopaedics (Lund) (013028000)
id
9a081150-a91a-453e-83df-4cf17e6fa4a7 (old id 1540802)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20087653?dopt=Abstract
date added to LUP
2016-04-04 09:25:32
date last changed
2022-03-23 05:31:12
@article{9a081150-a91a-453e-83df-4cf17e6fa4a7,
  abstract     = {{Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of 71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females treated by segmental resection, anti-hormonal treatment and radiotherapy 1980-2005 developed angiosarcomas in the irradiated field on the thoracic wall after median 7.3 years. The clinical presentations were heterogeneous and included hematoma-like lesions, multiple bluish-reddish nodules, and asymptomatic lumps. The overall 5-year survival was 16%. In this population-based cohort, the early angiosarcomas developed in edematous arms after radical mastectomies, whereas more recent cases occurred after a shorter time period in the irradiated fields following breast conserving surgery. We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer.}},
  author       = {{Styring, Emelie and Fernebro, Josefin and Jönsson, Per-Ebbe and Ehinger, Anna and Engellau, Jacob and Rissler, Pehr and Rydholm, Anders and Nilbert, Mef and Vult von Steyern, Fredrik}},
  issn         = {{1573-7217}},
  language     = {{eng}},
  pages        = {{883--887}},
  publisher    = {{Springer}},
  series       = {{Breast Cancer Research and Treatment}},
  title        = {{Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.}},
  url          = {{http://dx.doi.org/10.1007/s10549-009-0703-8}},
  doi          = {{10.1007/s10549-009-0703-8}},
  volume       = {{122}},
  year         = {{2010}},
}