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Effects of chronic clozapine administration on apolipoprotein D levels and on functional recovery following experimental stroke.

Ruscher, Karsten LU ; Erickson, Agnes LU ; Kuric, Enida LU ; Inacio, Ana LU and Wieloch, Tadeusz LU (2010) In Brain Research1966-01-01+01:00 1321. p.152-163
Abstract
Elevated brain levels of apolipoprotein D (ApoD) correlate with improved neurological recovery after experimental stroke. Hence, a pharmacological induction of ApoD in the postischemic brain could be beneficial for recovery after stroke. Here we investigated the effect of Clozapine, a compound that increases the expression of ApoD, in two rat models of experimental stroke. Rats were subjected to permanent occlusion of the middle cerebral artery (pMCAO) and treated with Clozapine (i.p. 10mg/kg body weight) or saline for 8 or 28days starting on the second day after MCAO. ApoD levels increased by 35% in the peri-infarct area after 10 and 30days after pMCAO, mainly in neuron-specific nuclear protein (NeuN) positive neurons and glial fibrillary... (More)
Elevated brain levels of apolipoprotein D (ApoD) correlate with improved neurological recovery after experimental stroke. Hence, a pharmacological induction of ApoD in the postischemic brain could be beneficial for recovery after stroke. Here we investigated the effect of Clozapine, a compound that increases the expression of ApoD, in two rat models of experimental stroke. Rats were subjected to permanent occlusion of the middle cerebral artery (pMCAO) and treated with Clozapine (i.p. 10mg/kg body weight) or saline for 8 or 28days starting on the second day after MCAO. ApoD levels increased by 35% in the peri-infarct area after 10 and 30days after pMCAO, mainly in neuron-specific nuclear protein (NeuN) positive neurons and glial fibrillary acidic protein (GFAP) positive astrocytes. Clozapine did not affect the neurological deficit assessed by the rotating pole test and a grip strength test at 7d, 14d, 21d, and 28days after pMCAO. Functional outcome and the infarct size were similar in rats subjected to transient MCAO and injected with Clozapine (i.p. 10mg/kg body weight) or saline for 26days starting on the second day after tMCAO. We conclude that Clozapine affects cellular processes involved in peri-infarct tissue reorganization, but does not affect functional recovery after MCAO. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Brain Research1966-01-01+01:00
volume
1321
pages
152 - 163
publisher
Elsevier
external identifiers
  • wos:000276120800017
  • pmid:20083089
  • scopus:77549084949
ISSN
1872-6240
DOI
language
English
LU publication?
yes
id
5d2602db-fa95-4ca5-8564-d4cb81d37084 (old id 1540854)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20083089?dopt=Abstract
date added to LUP
2010-02-03 11:28:59
date last changed
2018-05-29 10:10:10
@article{5d2602db-fa95-4ca5-8564-d4cb81d37084,
  abstract     = {Elevated brain levels of apolipoprotein D (ApoD) correlate with improved neurological recovery after experimental stroke. Hence, a pharmacological induction of ApoD in the postischemic brain could be beneficial for recovery after stroke. Here we investigated the effect of Clozapine, a compound that increases the expression of ApoD, in two rat models of experimental stroke. Rats were subjected to permanent occlusion of the middle cerebral artery (pMCAO) and treated with Clozapine (i.p. 10mg/kg body weight) or saline for 8 or 28days starting on the second day after MCAO. ApoD levels increased by 35% in the peri-infarct area after 10 and 30days after pMCAO, mainly in neuron-specific nuclear protein (NeuN) positive neurons and glial fibrillary acidic protein (GFAP) positive astrocytes. Clozapine did not affect the neurological deficit assessed by the rotating pole test and a grip strength test at 7d, 14d, 21d, and 28days after pMCAO. Functional outcome and the infarct size were similar in rats subjected to transient MCAO and injected with Clozapine (i.p. 10mg/kg body weight) or saline for 26days starting on the second day after tMCAO. We conclude that Clozapine affects cellular processes involved in peri-infarct tissue reorganization, but does not affect functional recovery after MCAO.},
  author       = {Ruscher, Karsten and Erickson, Agnes and Kuric, Enida and Inacio, Ana and Wieloch, Tadeusz},
  issn         = {1872-6240},
  language     = {eng},
  pages        = {152--163},
  publisher    = {Elsevier},
  series       = {Brain Research1966-01-01+01:00},
  title        = {Effects of chronic clozapine administration on apolipoprotein D levels and on functional recovery following experimental stroke.},
  url          = {http://dx.doi.org/},
  volume       = {1321},
  year         = {2010},
}