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Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia.

Ahnström, Josefin LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU (2010) In Clinical Biochemistry 43. p.599-603
Abstract
OBJECTIVES: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. DESIGN AND METHODS: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population. RESULTS: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p<0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was... (More)
OBJECTIVES: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. DESIGN AND METHODS: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population. RESULTS: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p<0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was independently associated with CLI, the odds ratio being 0.015. CONCLUSIONS: In subjects with CLI, plasma concentrations of apoA-I, apoB and apoM were significantly lower than in control individuals, but only apoA-I was independently associated to CLI. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
43
pages
599 - 603
publisher
Elsevier
external identifiers
  • wos:000276255000011
  • pmid:20080084
  • scopus:77950866515
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2010.01.001
language
English
LU publication?
yes
id
9981e9fe-5f4a-41ec-907c-6a560766a6f6 (old id 1541017)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20080084?dopt=Abstract
date added to LUP
2010-02-03 09:30:28
date last changed
2018-05-29 10:38:35
@article{9981e9fe-5f4a-41ec-907c-6a560766a6f6,
  abstract     = {OBJECTIVES: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. DESIGN AND METHODS: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population. RESULTS: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p&lt;0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was independently associated with CLI, the odds ratio being 0.015. CONCLUSIONS: In subjects with CLI, plasma concentrations of apoA-I, apoB and apoM were significantly lower than in control individuals, but only apoA-I was independently associated to CLI.},
  author       = {Ahnström, Josefin and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn},
  issn         = {1873-2933},
  language     = {eng},
  pages        = {599--603},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2010.01.001},
  volume       = {43},
  year         = {2010},
}