Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia.
(2010) In Clinical Biochemistry 43. p.599-603- Abstract
- OBJECTIVES: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. DESIGN AND METHODS: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population. RESULTS: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p<0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was... (More)
- OBJECTIVES: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. DESIGN AND METHODS: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population. RESULTS: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p<0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was independently associated with CLI, the odds ratio being 0.015. CONCLUSIONS: In subjects with CLI, plasma concentrations of apoA-I, apoB and apoM were significantly lower than in control individuals, but only apoA-I was independently associated to CLI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1541017
- author
- Ahnström, Josefin LU ; Gottsäter, Anders LU ; Lindblad, Bengt LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Biochemistry
- volume
- 43
- pages
- 599 - 603
- publisher
- Elsevier
- external identifiers
-
- wos:000276255000011
- pmid:20080084
- scopus:77950866515
- pmid:20080084
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2010.01.001
- language
- English
- LU publication?
- yes
- id
- 9981e9fe-5f4a-41ec-907c-6a560766a6f6 (old id 1541017)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20080084?dopt=Abstract
- date added to LUP
- 2016-04-04 08:16:29
- date last changed
- 2022-01-29 03:16:02
@article{9981e9fe-5f4a-41ec-907c-6a560766a6f6, abstract = {{OBJECTIVES: Apolipoproteins affect development of atherosclerosis, but their involvement in the pathogenesis of critical limb ischemia (CLI), a severe form of atherosclerosis, has not previously been examined. DESIGN AND METHODS: ApoA-I, apoB, and apoM were measured in plasma from 196 CLI subjects and 214 control individuals from the background population. RESULTS: Cases had lower levels of the apolipoproteins, as compared to controls; apoA-I, 1.23 vs. 2.08 g/L; apoB, 0.93 vs. 1.04 g/L; apoM, 0.75 vs. 0.91 mumol/L (p<0.0001 for all three). ApoA-I and apoM correlated negatively with inflammatory markers and positively to 1- and 3-year survival rates, whereas apoB did not. In multivariate analyses, apoA-I, but not apoB and apoM, was independently associated with CLI, the odds ratio being 0.015. CONCLUSIONS: In subjects with CLI, plasma concentrations of apoA-I, apoB and apoM were significantly lower than in control individuals, but only apoA-I was independently associated to CLI.}}, author = {{Ahnström, Josefin and Gottsäter, Anders and Lindblad, Bengt and Dahlbäck, Björn}}, issn = {{1873-2933}}, language = {{eng}}, pages = {{599--603}}, publisher = {{Elsevier}}, series = {{Clinical Biochemistry}}, title = {{Plasma concentrations of apolipoproteins A-I, B, and M in patients with critical limb ischemia.}}, url = {{http://dx.doi.org/10.1016/j.clinbiochem.2010.01.001}}, doi = {{10.1016/j.clinbiochem.2010.01.001}}, volume = {{43}}, year = {{2010}}, }