Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
(2010) In Cytokine 49. p.256-263- Abstract
- Objectives: The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand the variation of acute pulmonary inflammation between mouse strains. Methods: The present study investigated the susceptibility of acute production of inflammatory mediators, e.g. cytokines, chemokines and others, to LPS in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J, and C3H/HeN mice. Results: The susceptibility to intra-tracheal challenge with LPS varied between measured variables, durations and strains. General lung hyper-reactive susceptibility to LPS-induced pulmonary production of 6-8 inflammatory mediators followed the order NMRI,... (More)
- Objectives: The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand the variation of acute pulmonary inflammation between mouse strains. Methods: The present study investigated the susceptibility of acute production of inflammatory mediators, e.g. cytokines, chemokines and others, to LPS in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J, and C3H/HeN mice. Results: The susceptibility to intra-tracheal challenge with LPS varied between measured variables, durations and strains. General lung hyper-reactive susceptibility to LPS-induced pulmonary production of 6-8 inflammatory mediators followed the order NMRI, Balb/cJ, C3H/HeN, A/J, C57BL/6J, DBA/1J, DBA/2J and CD-1 mice at 4h, and A/J, C3H/HeN, CD-1, NMRI, C57BL/6J, Balb/cJ, DBA/2J and DBA/1J mice at 24h. Conclusions: Our data provide information for scientists to consider the proper strain of mice for the measurement of specific inflammatory mediators and to select sensitive or resistant mouse strains for understanding genetic variation in the pathogenesis and for the screening of target-oriented drug development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1541450
- author
- Alm, Ann-Sophie ; Li, Ka ; Yang, Dong ; Andersson, Roland LU ; Lu, You and Wang, Xiangdong LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cytokine
- volume
- 49
- pages
- 256 - 263
- publisher
- Academic Press
- external identifiers
-
- wos:000275353400004
- pmid:20042347
- scopus:75749142983
- ISSN
- 1096-0023
- DOI
- 10.1016/j.cyto.2009.11.007
- language
- English
- LU publication?
- yes
- id
- 07e4474c-3c0b-4d97-98b5-1b2daa073acf (old id 1541450)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20042347?dopt=Abstract
- date added to LUP
- 2016-04-04 09:12:28
- date last changed
- 2022-01-29 08:44:38
@article{07e4474c-3c0b-4d97-98b5-1b2daa073acf, abstract = {{Objectives: The lipopolysaccharide (LPS)-induced acute lung injury (ALI) model has been widely applied for pathophysiological and pharmacological research. The aim of present study is to understand the variation of acute pulmonary inflammation between mouse strains. Methods: The present study investigated the susceptibility of acute production of inflammatory mediators, e.g. cytokines, chemokines and others, to LPS in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J, and C3H/HeN mice. Results: The susceptibility to intra-tracheal challenge with LPS varied between measured variables, durations and strains. General lung hyper-reactive susceptibility to LPS-induced pulmonary production of 6-8 inflammatory mediators followed the order NMRI, Balb/cJ, C3H/HeN, A/J, C57BL/6J, DBA/1J, DBA/2J and CD-1 mice at 4h, and A/J, C3H/HeN, CD-1, NMRI, C57BL/6J, Balb/cJ, DBA/2J and DBA/1J mice at 24h. Conclusions: Our data provide information for scientists to consider the proper strain of mice for the measurement of specific inflammatory mediators and to select sensitive or resistant mouse strains for understanding genetic variation in the pathogenesis and for the screening of target-oriented drug development.}}, author = {{Alm, Ann-Sophie and Li, Ka and Yang, Dong and Andersson, Roland and Lu, You and Wang, Xiangdong}}, issn = {{1096-0023}}, language = {{eng}}, pages = {{256--263}}, publisher = {{Academic Press}}, series = {{Cytokine}}, title = {{Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.}}, url = {{http://dx.doi.org/10.1016/j.cyto.2009.11.007}}, doi = {{10.1016/j.cyto.2009.11.007}}, volume = {{49}}, year = {{2010}}, }