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Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38.

Hazard, Kristina LU ; Eliasson, Linda LU ; Dillner, Joakim LU and Forslund, Ola LU (2006) In International Journal of Cancer 119(5). p.1073-1077
Abstract
The human papillomaviruses (HPVs) exist as more than 100 distinct types. While variants of HPV are common, only few HPV subtypes have been reported. HPV type 38 has been proposed to be associated with nonmelanoma skin cancer (NMSC), with reported prevalences of up to 55%. A subtype of HPV38 was cloned, completely sequenced and found to have a 96% sequence similarity to prototype HPV38 in the L1 open reading frame. The presence of prototype HPV38 and HPV38b[FA125] was examined in paired biopsies of tape-stripped skin lesions and healthy skin from 269 immunocompetent patients by real-time PCR. Prototype HPV38 and HPV38b[FA125] were present in seven (3%) and five (2%) lesions, respectively, in viral loads ranging from one copy per 150 cells... (More)
The human papillomaviruses (HPVs) exist as more than 100 distinct types. While variants of HPV are common, only few HPV subtypes have been reported. HPV type 38 has been proposed to be associated with nonmelanoma skin cancer (NMSC), with reported prevalences of up to 55%. A subtype of HPV38 was cloned, completely sequenced and found to have a 96% sequence similarity to prototype HPV38 in the L1 open reading frame. The presence of prototype HPV38 and HPV38b[FA125] was examined in paired biopsies of tape-stripped skin lesions and healthy skin from 269 immunocompetent patients by real-time PCR. Prototype HPV38 and HPV38b[FA125] were present in seven (3%) and five (2%) lesions, respectively, in viral loads ranging from one copy per 150 cells to one copy per 70,000 cells. In summary, we found that HPV38 is heterogeneous and is one of so far only few HPVs that contain subtypes. The heterogeneity needs to be considered in studies of the biology of this virus. (c) 2006 Wiley-Liss, Inc. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
multiplyprimed rolling circle, HPV, subtype, amplification, nonmelanoma skin cancer
in
International Journal of Cancer
volume
119
issue
5
pages
1073 - 1077
publisher
John Wiley and Sons
external identifiers
  • wos:000239287800014
  • pmid:16557595
  • scopus:33746338612
  • pmid:16557595
ISSN
0020-7136
DOI
10.1002/ijc.21920
language
English
LU publication?
yes
id
d21a01e1-6c96-4fff-8110-0e4d37d12292 (old id 154419)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16557595&dopt=Abstract
date added to LUP
2016-04-01 12:03:17
date last changed
2021-09-15 05:03:07
@article{d21a01e1-6c96-4fff-8110-0e4d37d12292,
  abstract     = {The human papillomaviruses (HPVs) exist as more than 100 distinct types. While variants of HPV are common, only few HPV subtypes have been reported. HPV type 38 has been proposed to be associated with nonmelanoma skin cancer (NMSC), with reported prevalences of up to 55%. A subtype of HPV38 was cloned, completely sequenced and found to have a 96% sequence similarity to prototype HPV38 in the L1 open reading frame. The presence of prototype HPV38 and HPV38b[FA125] was examined in paired biopsies of tape-stripped skin lesions and healthy skin from 269 immunocompetent patients by real-time PCR. Prototype HPV38 and HPV38b[FA125] were present in seven (3%) and five (2%) lesions, respectively, in viral loads ranging from one copy per 150 cells to one copy per 70,000 cells. In summary, we found that HPV38 is heterogeneous and is one of so far only few HPVs that contain subtypes. The heterogeneity needs to be considered in studies of the biology of this virus. (c) 2006 Wiley-Liss, Inc.},
  author       = {Hazard, Kristina and Eliasson, Linda and Dillner, Joakim and Forslund, Ola},
  issn         = {0020-7136},
  language     = {eng},
  number       = {5},
  pages        = {1073--1077},
  publisher    = {John Wiley and Sons},
  series       = {International Journal of Cancer},
  title        = {Subtype HPV38b[FA125] demonstrates heterogeneity of human papillomavirus type 38.},
  url          = {https://lup.lub.lu.se/search/files/2761382/625368.pdf},
  doi          = {10.1002/ijc.21920},
  volume       = {119},
  year         = {2006},
}