The epidemiology of Lp-PLA(2): Distribution and correlation with cardiovascular risk factors in a population-based cohort.
(2007) In Atherosclerosis 190. p.388-396- Abstract
- Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmo Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2)... (More)
- Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmo Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2) activity and mass in this study (r = 0.57). Highest correlations were observed between Lp-PLA(2) activity and LDL (r=0.45) and LDL/HDL ratio (r=0.54) and a strong inverse correlation to HDL (r=-0.31). The correlations between Lp-PLA(2) mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA(2) activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA(2) is strongly correlated with several cardiovascular risk factors, especially lipid fractions, and with the degree of carotid artery atherosclerosis. However, the measured variables accounted for only 19% and 35% of the variation in Lp-PLA(2) mass and activity respectively. (c) 2006 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/154710
- author
- Persson, Margaretha LU ; Nilsson, Jan-Åke LU ; Nelson, Jeanenne J ; Hedblad, Bo LU and Berglund, Göran LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- epidemiology, cardiovascular disease, Lp-PLA(2), risk factor
- in
- Atherosclerosis
- volume
- 190
- pages
- 388 - 396
- publisher
- Elsevier
- external identifiers
-
- wos:000244173000020
- scopus:33846061194
- ISSN
- 1879-1484
- DOI
- 10.1016/j.atherosclerosis.2006.02.016
- language
- English
- LU publication?
- yes
- id
- 6daebe0c-dc18-4741-b06a-9a6325a6f899 (old id 154710)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16530769&dopt=Abstract
- date added to LUP
- 2016-04-01 11:32:47
- date last changed
- 2024-02-22 21:08:11
@article{6daebe0c-dc18-4741-b06a-9a6325a6f899, abstract = {{Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmo Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2) activity and mass in this study (r = 0.57). Highest correlations were observed between Lp-PLA(2) activity and LDL (r=0.45) and LDL/HDL ratio (r=0.54) and a strong inverse correlation to HDL (r=-0.31). The correlations between Lp-PLA(2) mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA(2) activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA(2) is strongly correlated with several cardiovascular risk factors, especially lipid fractions, and with the degree of carotid artery atherosclerosis. However, the measured variables accounted for only 19% and 35% of the variation in Lp-PLA(2) mass and activity respectively. (c) 2006 Elsevier Ireland Ltd. All rights reserved.}}, author = {{Persson, Margaretha and Nilsson, Jan-Åke and Nelson, Jeanenne J and Hedblad, Bo and Berglund, Göran}}, issn = {{1879-1484}}, keywords = {{epidemiology; cardiovascular disease; Lp-PLA(2); risk factor}}, language = {{eng}}, pages = {{388--396}}, publisher = {{Elsevier}}, series = {{Atherosclerosis}}, title = {{The epidemiology of Lp-PLA(2): Distribution and correlation with cardiovascular risk factors in a population-based cohort.}}, url = {{https://lup.lub.lu.se/search/files/2538466/625372.pdf}}, doi = {{10.1016/j.atherosclerosis.2006.02.016}}, volume = {{190}}, year = {{2007}}, }