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The epidemiology of Lp-PLA(2): Distribution and correlation with cardiovascular risk factors in a population-based cohort.

Persson, Margaretha LU ; Nilsson, Jan-Åke LU ; Nelson, Jeanenne J; Hedblad, Bo LU and Berglund, Göran LU (2007) In Atherosclerosis 190. p.388-396
Abstract
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmo Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2)... (More)
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmo Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2) activity and mass in this study (r = 0.57). Highest correlations were observed between Lp-PLA(2) activity and LDL (r=0.45) and LDL/HDL ratio (r=0.54) and a strong inverse correlation to HDL (r=-0.31). The correlations between Lp-PLA(2) mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA(2) activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA(2) is strongly correlated with several cardiovascular risk factors, especially lipid fractions, and with the degree of carotid artery atherosclerosis. However, the measured variables accounted for only 19% and 35% of the variation in Lp-PLA(2) mass and activity respectively. (c) 2006 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, cardiovascular disease, Lp-PLA(2), risk factor
in
Atherosclerosis
volume
190
pages
388 - 396
publisher
Elsevier
external identifiers
  • wos:000244173000020
  • scopus:33846061194
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2006.02.016
language
English
LU publication?
yes
id
6daebe0c-dc18-4741-b06a-9a6325a6f899 (old id 154710)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16530769&dopt=Abstract
date added to LUP
2007-07-30 09:21:23
date last changed
2017-09-17 04:26:53
@article{6daebe0c-dc18-4741-b06a-9a6325a6f899,
  abstract     = {Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells (macrophages, T-lymphocytes and mast cells) and hydrolyzes oxidized phospholipids in LDL. Several epidemiology studies indicate that Lp-PLA(2) appears to be an independent marker of cardiovascular risk. This study was conducted to define the distribution of Lp-PLA(2) in a large population-based cohort and to determine associations between Lp-PLA(2) and other risk factors for CVD. The study group consisted of participants from the Malmo Diet and Cancer study (1992-1994). Lp-PLA(2) (activity and mass) was measured from samples obtained at baseline for 5402 participants (3167 women). A strong correlation was observed between Lp-PLA(2) activity and mass in this study (r = 0.57). Highest correlations were observed between Lp-PLA(2) activity and LDL (r=0.45) and LDL/HDL ratio (r=0.54) and a strong inverse correlation to HDL (r=-0.31). The correlations between Lp-PLA(2) mass and lipids were not as strong as the correlation between activity and lipids. Lp-PLA(2) activity and mass were correlated with increased ultrasound determined carotid intima-media thickness. We conclude that Lp-PLA(2) is strongly correlated with several cardiovascular risk factors, especially lipid fractions, and with the degree of carotid artery atherosclerosis. However, the measured variables accounted for only 19% and 35% of the variation in Lp-PLA(2) mass and activity respectively. (c) 2006 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Persson, Margaretha and Nilsson, Jan-Åke and Nelson, Jeanenne J and Hedblad, Bo and Berglund, Göran},
  issn         = {1879-1484},
  keyword      = {epidemiology,cardiovascular disease,Lp-PLA(2),risk factor},
  language     = {eng},
  pages        = {388--396},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {The epidemiology of Lp-PLA(2): Distribution and correlation with cardiovascular risk factors in a population-based cohort.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2006.02.016},
  volume       = {190},
  year         = {2007},
}