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Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training

Petersen, S. G.; Saxne, Tore LU ; Heinegård, Dick LU ; Hansen, M.; Holm, L.; Koskinen, S.; Stordal, C.; Christensen, H.; Aagaard, P. and Kjaer, M. (2010) In Osteoarthritis and Cartilage 18(1). p.34-40
Abstract
Objective: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo. Design: A 12-week double blind, placebo controlled, randomized study. Method: Thirty-six elderly patients with bilateral tibiofemoral knee OA determined by radiography were randomly assigned to treatment with glucosamine (n = 12), ibuprofen (n = 12) or placebo (n = 12) during 12 weeks of strength training of both legs with focus on the quadriceps muscle. Strength tests (5 repetition maximum), blood and... (More)
Objective: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo. Design: A 12-week double blind, placebo controlled, randomized study. Method: Thirty-six elderly patients with bilateral tibiofemoral knee OA determined by radiography were randomly assigned to treatment with glucosamine (n = 12), ibuprofen (n = 12) or placebo (n = 12) during 12 weeks of strength training of both legs with focus on the quadriceps muscle. Strength tests (5 repetition maximum), blood and urine sampling were performed before and after the training period. Serum COMP and urinary CTX-II were measured by enzyme-linked immunosorbent assay (ELISA). Results: All three groups increased their muscle strength following 12 weeks of strength training (P < 0.001). Serum COMP levels were reduced in the glucosamine-treated group after the training period (P = 0.012), whereas they did not change in the two other groups. Glucosamine reduced COMP statistically significant compared to both placebo and ibuprofen; the mean reduction with glucosamine was 13% vs placebo (P = 0.0378) and 17% vs ibuprofen (P = 0.0122). Urinary CTX-II levels did not change significantly in any of the three experimental groups. Conclusion: Serum COMP decreased significantly over the 12-week training period when treatment with glucosamine was added to the training regimen. This suggests an effect by glucosamine on the response of the OA cartilage to a period of joint loading in humans with knee OA. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cartilage oligomeric matrix protein, osteoarthritis, Knee, Exercise, Ibuprofen, NSAID, Glucosamine, Dietary supplement, c-Telopeptide of, type II collagen
in
Osteoarthritis and Cartilage
volume
18
issue
1
pages
34 - 40
publisher
Elsevier
external identifiers
  • wos:000273677500006
  • scopus:72449202633
ISSN
1063-4584
DOI
10.1016/j.joca.2009.07.004
language
English
LU publication?
yes
id
a458ce3d-235d-48fd-b35c-6f5295a2351a (old id 1547458)
date added to LUP
2010-02-23 14:13:39
date last changed
2018-05-29 09:32:43
@article{a458ce3d-235d-48fd-b35c-6f5295a2351a,
  abstract     = {Objective: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo. Design: A 12-week double blind, placebo controlled, randomized study. Method: Thirty-six elderly patients with bilateral tibiofemoral knee OA determined by radiography were randomly assigned to treatment with glucosamine (n = 12), ibuprofen (n = 12) or placebo (n = 12) during 12 weeks of strength training of both legs with focus on the quadriceps muscle. Strength tests (5 repetition maximum), blood and urine sampling were performed before and after the training period. Serum COMP and urinary CTX-II were measured by enzyme-linked immunosorbent assay (ELISA). Results: All three groups increased their muscle strength following 12 weeks of strength training (P &lt; 0.001). Serum COMP levels were reduced in the glucosamine-treated group after the training period (P = 0.012), whereas they did not change in the two other groups. Glucosamine reduced COMP statistically significant compared to both placebo and ibuprofen; the mean reduction with glucosamine was 13% vs placebo (P = 0.0378) and 17% vs ibuprofen (P = 0.0122). Urinary CTX-II levels did not change significantly in any of the three experimental groups. Conclusion: Serum COMP decreased significantly over the 12-week training period when treatment with glucosamine was added to the training regimen. This suggests an effect by glucosamine on the response of the OA cartilage to a period of joint loading in humans with knee OA. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
  author       = {Petersen, S. G. and Saxne, Tore and Heinegård, Dick and Hansen, M. and Holm, L. and Koskinen, S. and Stordal, C. and Christensen, H. and Aagaard, P. and Kjaer, M.},
  issn         = {1063-4584},
  keyword      = {Cartilage oligomeric matrix protein,osteoarthritis,Knee,Exercise,Ibuprofen,NSAID,Glucosamine,Dietary supplement,c-Telopeptide of,type II collagen},
  language     = {eng},
  number       = {1},
  pages        = {34--40},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training},
  url          = {http://dx.doi.org/10.1016/j.joca.2009.07.004},
  volume       = {18},
  year         = {2010},
}