Identification of collagen-induced arthritis loci in aged multiparous female mice.
(2006) In Arthritis Research and Therapy 8(2). p.45-45- Abstract
- Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide... (More)
- Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide screening with 125 microsatellite markers. We found one new significant quantitative trait locus affecting the arthritis incidence, severity and day of onset on chromosome 11 (denoted Cia40), which colocalizes with a locus controlling pregnancy failure. Furthermore, a quantitative trait locus of suggestive significance associated with the incidence, severity and day of onset was identified on chromosome 1. Finally, a suggestively significant quantitative trait locus associated with collagen type II antibody titers was identified on chromosome 13. This study indicates that several gene loci control arthritis in aged multiparous females, and that at least one of these loci coincides with pregnancy failure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/154898
- author
- Liljander, Maria LU ; Micha Frisk, Mary-Ann LU ; Andersson, Sara LU ; Andersson, Asa ; Holmdahl, Rikard LU and Mattsson, Ragnar LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arthritis Research and Therapy
- volume
- 8
- issue
- 2
- pages
- 45 - 45
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:16507151
- wos:000237648600017
- scopus:34247550959
- pmid:16507151
- ISSN
- 1478-6362
- DOI
- 10.1186/ar1901
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019), BMC Biomedical Centre (0130322000)
- id
- c62446a4-d3da-4520-9cde-af8455774906 (old id 154898)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16507151&dopt=Abstract
- date added to LUP
- 2016-04-01 12:02:52
- date last changed
- 2024-07-04 11:21:15
@article{c62446a4-d3da-4520-9cde-af8455774906,
abstract = {{Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis. Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes. Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype). The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease. A total of 200 female mice were used in a total genome-wide screening with 125 microsatellite markers. We found one new significant quantitative trait locus affecting the arthritis incidence, severity and day of onset on chromosome 11 (denoted Cia40), which colocalizes with a locus controlling pregnancy failure. Furthermore, a quantitative trait locus of suggestive significance associated with the incidence, severity and day of onset was identified on chromosome 1. Finally, a suggestively significant quantitative trait locus associated with collagen type II antibody titers was identified on chromosome 13. This study indicates that several gene loci control arthritis in aged multiparous females, and that at least one of these loci coincides with pregnancy failure.}},
author = {{Liljander, Maria and Micha Frisk, Mary-Ann and Andersson, Sara and Andersson, Asa and Holmdahl, Rikard and Mattsson, Ragnar}},
issn = {{1478-6362}},
language = {{eng}},
number = {{2}},
pages = {{45--45}},
publisher = {{BioMed Central (BMC)}},
series = {{Arthritis Research and Therapy}},
title = {{Identification of collagen-induced arthritis loci in aged multiparous female mice.}},
url = {{http://dx.doi.org/10.1186/ar1901}},
doi = {{10.1186/ar1901}},
volume = {{8}},
year = {{2006}},
}