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Variation in the innate and acquired arms of the immune system among five shorebird species

Mendes, L ; Piersma, T ; Hasselquist, Dennis LU ; Matson, K D and Ricklefs, R E (2006) In Journal of Experimental Biology 209(2). p.284-291
Abstract
To contribute to an understanding of the evolutionary processes that shape variation in immune responses, we compared several components of the innate and acquired arms of the immune system in five related, but ecologically diverse, migratory shorebirds (ruff Philomachus pugnax L., ruddy turnstone Arenaria interpres L., bar-tailed godwit Limosa lapponica L., sanderling Calidris alba Pallas and red knot C. canutus L.). We used a hemolysis-hemagglutination assay in free-living shorebirds to assess two of the innate components (natural antibodies and complement-mediated lysis), and a modified quantitative enzyme-linked immunosorbent assay in birds held in captivity to assess the acquired component (humoral antibodies against tetanus and... (More)
To contribute to an understanding of the evolutionary processes that shape variation in immune responses, we compared several components of the innate and acquired arms of the immune system in five related, but ecologically diverse, migratory shorebirds (ruff Philomachus pugnax L., ruddy turnstone Arenaria interpres L., bar-tailed godwit Limosa lapponica L., sanderling Calidris alba Pallas and red knot C. canutus L.). We used a hemolysis-hemagglutination assay in free-living shorebirds to assess two of the innate components (natural antibodies and complement-mediated lysis), and a modified quantitative enzyme-linked immunosorbent assay in birds held in captivity to assess the acquired component (humoral antibodies against tetanus and diphtheria toxoid) of immunity. Ruddy turnstones showed the highest levels of both innate and acquired immune responses. We suggest that turnstones could have evolved strong immune responses because they scavenge among rotting organic material on the seashore, where they might be exposed to a particularly broad range of pathogens. Although ruffs stand out among shorebirds in having a high prevalence of avian malaria, they do not exhibit higher immune response levels. Our results indicate that relationships between immune response and infection are not likely to follow a broad general pattern, but instead depend on type of parasite exposure, among other factors. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Experimental Biology
volume
209
issue
2
pages
284 - 291
publisher
The Company of Biologists Ltd
external identifiers
  • wos:000235318600012
  • pmid:16391350
  • scopus:32544460719
  • pmid:16391350
ISSN
1477-9145
DOI
10.1242/jeb.02015
language
English
LU publication?
yes
id
7eee5266-dc66-4ee4-b6ce-596aafb7d5e1 (old id 155278)
alternative location
http://jeb.biologists.org/cgi/reprint/209/2/284
date added to LUP
2016-04-01 12:33:49
date last changed
2020-09-23 15:18:49
@article{7eee5266-dc66-4ee4-b6ce-596aafb7d5e1,
  abstract     = {To contribute to an understanding of the evolutionary processes that shape variation in immune responses, we compared several components of the innate and acquired arms of the immune system in five related, but ecologically diverse, migratory shorebirds (ruff Philomachus pugnax L., ruddy turnstone Arenaria interpres L., bar-tailed godwit Limosa lapponica L., sanderling Calidris alba Pallas and red knot C. canutus L.). We used a hemolysis-hemagglutination assay in free-living shorebirds to assess two of the innate components (natural antibodies and complement-mediated lysis), and a modified quantitative enzyme-linked immunosorbent assay in birds held in captivity to assess the acquired component (humoral antibodies against tetanus and diphtheria toxoid) of immunity. Ruddy turnstones showed the highest levels of both innate and acquired immune responses. We suggest that turnstones could have evolved strong immune responses because they scavenge among rotting organic material on the seashore, where they might be exposed to a particularly broad range of pathogens. Although ruffs stand out among shorebirds in having a high prevalence of avian malaria, they do not exhibit higher immune response levels. Our results indicate that relationships between immune response and infection are not likely to follow a broad general pattern, but instead depend on type of parasite exposure, among other factors.},
  author       = {Mendes, L and Piersma, T and Hasselquist, Dennis and Matson, K D and Ricklefs, R E},
  issn         = {1477-9145},
  language     = {eng},
  number       = {2},
  pages        = {284--291},
  publisher    = {The Company of Biologists Ltd},
  series       = {Journal of Experimental Biology},
  title        = {Variation in the innate and acquired arms of the immune system among five shorebird species},
  url          = {https://lup.lub.lu.se/search/ws/files/2974342/625384.pdf},
  doi          = {10.1242/jeb.02015},
  volume       = {209},
  year         = {2006},
}