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Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome?

Källén, Bengt LU ; Finnström, Orvar; Lindam, Anna; Nilsson, Emma LU ; Nygren, Karl-Gösta and Olausson, Petra Otterblad (2010) In Fertility and Sterility 94. p.1680-1683
Abstract
OBJECTIVE: To compare neonatal outcome of blastocyst and cleavage stage embryo transfers after IVF. DESIGN: Register study. PATIENT(S): Treatments reported from all Swedish IVF clinics. INTERVENTION(S): None. SETTING: Births recorded in the Swedish Medical Birth Register after IVF performed, 2002-2006. MAIN OUTCOME MEASURE(S): Some neonatal characteristics were compared in 1,311 infants born after blastocyst-stage transfer and 12,562 infants born after cleavage-stage transfer. Comparisons were also made with all births, 2002-2007 (n = 598,687). RESULT(S): After adjusting for year of birth, maternal age, parity, smoking habits, and body mass index, the risk of preterm birth among singletons was significantly greater after blastocyst-stage... (More)
OBJECTIVE: To compare neonatal outcome of blastocyst and cleavage stage embryo transfers after IVF. DESIGN: Register study. PATIENT(S): Treatments reported from all Swedish IVF clinics. INTERVENTION(S): None. SETTING: Births recorded in the Swedish Medical Birth Register after IVF performed, 2002-2006. MAIN OUTCOME MEASURE(S): Some neonatal characteristics were compared in 1,311 infants born after blastocyst-stage transfer and 12,562 infants born after cleavage-stage transfer. Comparisons were also made with all births, 2002-2007 (n = 598,687). RESULT(S): After adjusting for year of birth, maternal age, parity, smoking habits, and body mass index, the risk of preterm birth among singletons was significantly greater after blastocyst-stage transfer than after cleavage-stage transfer. The risk of congenital malformations was also significantly higher. When the analysis was restricted to clinics where blastocyst transfers were made, the risk estimates increased for preterm birth, low birth weight, low APGAR score, and respiratory diagnoses, but did not change for congenital malformations. CONCLUSION(S): The results indicate a small increase in risk associated with blastocyst transfer, perhaps owing to the longer period of in vitro culture. There is a possibility that this effect is due, at least in part, to a selection of women for blastocyst transfers. Further studies are needed either to verify or to refute the found associations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Fertility and Sterility
volume
94
pages
1680 - 1683
publisher
Elsevier
external identifiers
  • wos:000282160600020
  • pmid:20137785
  • scopus:77957191234
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2009.12.027
language
English
LU publication?
yes
id
f4a79b1a-2b67-44ff-a8bd-d4ef376a541a (old id 1552879)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20137785?dopt=Abstract
date added to LUP
2010-03-02 21:22:35
date last changed
2018-05-29 10:52:43
@article{f4a79b1a-2b67-44ff-a8bd-d4ef376a541a,
  abstract     = {OBJECTIVE: To compare neonatal outcome of blastocyst and cleavage stage embryo transfers after IVF. DESIGN: Register study. PATIENT(S): Treatments reported from all Swedish IVF clinics. INTERVENTION(S): None. SETTING: Births recorded in the Swedish Medical Birth Register after IVF performed, 2002-2006. MAIN OUTCOME MEASURE(S): Some neonatal characteristics were compared in 1,311 infants born after blastocyst-stage transfer and 12,562 infants born after cleavage-stage transfer. Comparisons were also made with all births, 2002-2007 (n = 598,687). RESULT(S): After adjusting for year of birth, maternal age, parity, smoking habits, and body mass index, the risk of preterm birth among singletons was significantly greater after blastocyst-stage transfer than after cleavage-stage transfer. The risk of congenital malformations was also significantly higher. When the analysis was restricted to clinics where blastocyst transfers were made, the risk estimates increased for preterm birth, low birth weight, low APGAR score, and respiratory diagnoses, but did not change for congenital malformations. CONCLUSION(S): The results indicate a small increase in risk associated with blastocyst transfer, perhaps owing to the longer period of in vitro culture. There is a possibility that this effect is due, at least in part, to a selection of women for blastocyst transfers. Further studies are needed either to verify or to refute the found associations.},
  author       = {Källén, Bengt and Finnström, Orvar and Lindam, Anna and Nilsson, Emma and Nygren, Karl-Gösta and Olausson, Petra Otterblad},
  issn         = {1556-5653},
  language     = {eng},
  pages        = {1680--1683},
  publisher    = {Elsevier},
  series       = {Fertility and Sterility},
  title        = {Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome?},
  url          = {http://dx.doi.org/10.1016/j.fertnstert.2009.12.027},
  volume       = {94},
  year         = {2010},
}