Advanced

From the bone marrow to the thymus: the road map of early stages of T-cell development.

Sitnicka Quinn, Ewa LU (2009) In Critical Reviews in Immunology 29(6). p.487-530
Abstract
The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the... (More)
The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T-Lymphocytes: immunology, Thymus Gland: cytology, Thymus Gland: immunology, Bone Marrow: immunology, T-Lymphocytes: cytology
in
Critical Reviews in Immunology
volume
29
issue
6
pages
487 - 530
publisher
Begell House
external identifiers
  • wos:000274695900003
  • pmid:20121697
  • scopus:76749136189
ISSN
1040-8401
DOI
10.1615/CritRevImmunol.v29.i6.30
language
English
LU publication?
yes
id
bb2b3f8b-9959-4a64-83c1-3910a8fbfd32 (old id 1553086)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20121697?dopt=Abstract
date added to LUP
2010-03-02 17:25:02
date last changed
2017-01-12 11:13:47
@article{bb2b3f8b-9959-4a64-83c1-3910a8fbfd32,
  abstract     = {The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus.},
  author       = {Sitnicka Quinn, Ewa},
  issn         = {1040-8401},
  keyword      = {T-Lymphocytes: immunology,Thymus Gland: cytology,Thymus Gland: immunology,Bone Marrow: immunology,T-Lymphocytes: cytology},
  language     = {eng},
  number       = {6},
  pages        = {487--530},
  publisher    = {Begell House},
  series       = {Critical Reviews in Immunology},
  title        = {From the bone marrow to the thymus: the road map of early stages of T-cell development.},
  url          = {http://dx.doi.org/10.1615/CritRevImmunol.v29.i6.30},
  volume       = {29},
  year         = {2009},
}