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Genetically modified animals in research : an analysis of applications submitted to ethics committees on animal experimentation in Sweden

Nordgren, Anders and Röcklinsberg, Helena LU (2005) In Animal Welfare 14(3). p.239-248
Abstract
The use of genetically modified animals in biomedical research has increased during recent years and its ethical aspects have been subject to academic discussion. In order to make this discussion more concrete, we analyzed applications submitted to animal ethics committees in Sweden in 2002. The aim was to investigate the researchers’ statements concerning the production and use of genetically modified animals as well as the committees’ assessments. For our analysis, we constructed an Analytic Form. In part, we followed the questions and categories of the mandatory Application Form, noting for example species, degree of severity as regards pain and distress, handling of pain, and endpoints. In part, we created questions and categories of... (More)
The use of genetically modified animals in biomedical research has increased during recent years and its ethical aspects have been subject to academic discussion. In order to make this discussion more concrete, we analyzed applications submitted to animal ethics committees in Sweden in 2002. The aim was to investigate the researchers’ statements concerning the production and use of genetically modified animals as well as the committees’ assessments. For our analysis, we constructed an Analytic Form. In part, we followed the questions and categories of the mandatory Application Form, noting for example species, degree of severity as regards pain and distress, handling of pain, and endpoints. In part, we created questions and categories of our own and classified the applications accordingly. We focused particularly on methods of production and on expected clinical symptoms due to genetic modification and experimental use. Our analysis – partly quantitative, partly qualitative – showed, inter alia, that applications were often approved in spite of insufficient information regarding ethically relevant aspects, that the arguments for using genetically modified animals were often unclear, and that some applicants indicated awareness of the possibility of unintended welfare effects due to genetic modification, while others did not. We noted that many applicants stressed that certain GM animals were to be used without manifesting any clinical symptoms. This was obviously viewed as an ethical advantage. We found that obvious or minor clinical symptoms due to genetic modification were expected in more than a third of the applications. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transgenic animals, animal welfare, animal experimentation, animal ethics, genetically modified animals, animal ethics committees
in
Animal Welfare
volume
14
issue
3
pages
239 - 248
publisher
Universities Federation for Animal welfare
external identifiers
  • wos:000230860200008
  • scopus:23044448822
ISSN
0962-7286
language
English
LU publication?
yes
id
2dd63aa6-13b3-4162-bb33-cd8a169e9961 (old id 155429)
alternative location
http://www.ingentaconnect.com/content/ufaw/aw/2005/00000014/00000003/art00008;jsessionid=1guqy1s9u9x7r.henrietta
date added to LUP
2007-07-20 11:24:12
date last changed
2017-01-01 07:16:06
@article{2dd63aa6-13b3-4162-bb33-cd8a169e9961,
  abstract     = {The use of genetically modified animals in biomedical research has increased during recent years and its ethical aspects have been subject to academic discussion. In order to make this discussion more concrete, we analyzed applications submitted to animal ethics committees in Sweden in 2002. The aim was to investigate the researchers’ statements concerning the production and use of genetically modified animals as well as the committees’ assessments. For our analysis, we constructed an Analytic Form. In part, we followed the questions and categories of the mandatory Application Form, noting for example species, degree of severity as regards pain and distress, handling of pain, and endpoints. In part, we created questions and categories of our own and classified the applications accordingly. We focused particularly on methods of production and on expected clinical symptoms due to genetic modification and experimental use. Our analysis – partly quantitative, partly qualitative – showed, inter alia, that applications were often approved in spite of insufficient information regarding ethically relevant aspects, that the arguments for using genetically modified animals were often unclear, and that some applicants indicated awareness of the possibility of unintended welfare effects due to genetic modification, while others did not. We noted that many applicants stressed that certain GM animals were to be used without manifesting any clinical symptoms. This was obviously viewed as an ethical advantage. We found that obvious or minor clinical symptoms due to genetic modification were expected in more than a third of the applications.},
  author       = {Nordgren, Anders and Röcklinsberg, Helena},
  issn         = {0962-7286},
  keyword      = {transgenic animals,animal welfare,animal experimentation,animal ethics,genetically modified animals,animal ethics committees},
  language     = {eng},
  number       = {3},
  pages        = {239--248},
  publisher    = {Universities Federation for Animal welfare},
  series       = {Animal Welfare},
  title        = {Genetically modified animals in research : an analysis of applications submitted to ethics committees on animal experimentation in Sweden},
  volume       = {14},
  year         = {2005},
}