Tumor extension in high-grade gliomas assessed with diffusion magnetic resonance imaging: values and lesion-to-brain ratios of apparent diffusion coefficient and fractional anisotropy.
van Westen, Danielle LU
; Lätt, Jimmy
LU
; Englund, Elisabet
LU
; Brockstedt, Sara
LU
and Larsson, Elna-Marie
LU
(2006)
In Acta Radiologica
47(3).
p.311-319
- Abstract
- Purpose: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.
Material and Methods: Thirty patients were studied: 18 WHO grade III or IV gliomas, 7 meningiomas, and 5 metastatic lesions. ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain. Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.
Results: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with... (More) - Purpose: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.
Material and Methods: Thirty patients were studied: 18 WHO grade III or IV gliomas, 7 meningiomas, and 5 metastatic lesions. ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain. Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.
Results: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with T2-signal changes did not differ between gliomas, meningiomas, and metastases (P = 0.40, P = 0.40, P = 0.61, P = 0.34). Values of ADC and FA and the lesion-to-brain ratio of FA in the adjacent NAWM did not differ between tumor types (P = 0.74, P = 0.25, and P = 0.31). The lesion-to-brain ratio of ADC in the adjacent NAWM was higher in gliomas than in meningiomas and metastases (P = 0.004), but overlapped between tumor types.
Conclusion: Values and lesion-to-brain ratios of ADC and FA in areas with T2-signal changes surrounding intracranial tumors and adjacent NAWM were not helpful for distinguishing pure edema from tumor-infiltrated edema when data from gliomas, meningiomas, and metastases were compared. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/155912
- author
- van Westen, Danielle
LU
; Lätt, Jimmy
LU
; Englund, Elisabet
LU
; Brockstedt, Sara
LU
and Larsson, Elna-Marie
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain tumors, diffusion weighted imaging, diffusion tensor imaging, magnetic resonance imaging
- in
- Acta Radiologica
- volume
- 47
- issue
- 3
- pages
- 311 - 319
- publisher
- SAGE Publications
- external identifiers
-
- wos:000236669600015
- pmid:16613314
- scopus:33646244250
- ISSN
- 1600-0455
- DOI
- 10.1080/02841850500539058
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diagnostic Radiology, (Lund) (013038000), Pathology, (Lund) (013030000), Radiation Physics, Lund (013034000)
- id
- eb61d60a-e6cc-4c94-8d3f-c8b71ec1c617 (old id 155912)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16613314&dopt=Abstract
- date added to LUP
- 2016-04-01 16:46:09
- date last changed
- 2022-03-15 02:49:51
@article{eb61d60a-e6cc-4c94-8d3f-c8b71ec1c617,
abstract = {{Purpose: To determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema in gliomas from pure edema in meningiomas and metastases.<br/><br>
<br/><br>
Material and Methods: Thirty patients were studied: 18 WHO grade III or IV gliomas, 7 meningiomas, and 5 metastatic lesions. ADC and FA were determined from ROIs placed in peritumoral areas with T2-signal changes, adjacent normal appearing white matter (NAWM), and corresponding areas in the contralateral healthy brain. Values and lesion-to-brain ratios from gliomas were compared to those from meningiomas and metastases.<br/><br>
<br/><br>
Results: Values and lesion-to-brain ratios of ADC and FA in peritumoral areas with T2-signal changes did not differ between gliomas, meningiomas, and metastases (P = 0.40, P = 0.40, P = 0.61, P = 0.34). Values of ADC and FA and the lesion-to-brain ratio of FA in the adjacent NAWM did not differ between tumor types (P = 0.74, P = 0.25, and P = 0.31). The lesion-to-brain ratio of ADC in the adjacent NAWM was higher in gliomas than in meningiomas and metastases (P = 0.004), but overlapped between tumor types.<br/><br>
<br/><br>
Conclusion: Values and lesion-to-brain ratios of ADC and FA in areas with T2-signal changes surrounding intracranial tumors and adjacent NAWM were not helpful for distinguishing pure edema from tumor-infiltrated edema when data from gliomas, meningiomas, and metastases were compared.}},
author = {{van Westen, Danielle and Lätt, Jimmy and Englund, Elisabet and Brockstedt, Sara and Larsson, Elna-Marie}},
issn = {{1600-0455}},
keywords = {{Brain tumors; diffusion weighted imaging; diffusion tensor imaging; magnetic resonance imaging}},
language = {{eng}},
number = {{3}},
pages = {{311--319}},
publisher = {{SAGE Publications}},
series = {{Acta Radiologica}},
title = {{Tumor extension in high-grade gliomas assessed with diffusion magnetic resonance imaging: values and lesion-to-brain ratios of apparent diffusion coefficient and fractional anisotropy.}},
url = {{http://dx.doi.org/10.1080/02841850500539058}},
doi = {{10.1080/02841850500539058}},
volume = {{47}},
year = {{2006}},
}