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Genetics of autoimmune diseases: a multistep process.

Johannesson, Martina LU ; Hultqvist, Malin LU and Holmdahl, Rikard LU (2006)
Abstract
Abstract in Undetermined
It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes in animal models for RA resulted in the identification of one of the genes regulating severity of arthritis in rats and mice, the Ncf1 gene. The Ncf1 gene encodes for the Ncf1 protein that is involved in production of free oxygen radicals through the NADPH oxidase complex, which opens up a new pathway for therapeutic treatment of inflammatory diseases. in most cases, however, a quantitative trait... (More)
Abstract in Undetermined
It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes in animal models for RA resulted in the identification of one of the genes regulating severity of arthritis in rats and mice, the Ncf1 gene. The Ncf1 gene encodes for the Ncf1 protein that is involved in production of free oxygen radicals through the NADPH oxidase complex, which opens up a new pathway for therapeutic treatment of inflammatory diseases. in most cases, however, a quantitative trait locus (QTL) is the sum effect of several genes within and outside the QTL, which make positional cloning difficult. Here we will discuss the possibilities and difficulties of gene identification in animal models of autoimmune disorders. (Less)
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publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology)
issue
305
publisher
Springer
external identifiers
  • pmid:16724810
  • wos:000238216500013
  • scopus:33744997425
ISSN
0070-217X
ISBN
978-3-540-29713-0
DOI
10.1007/3-540-29714-6_13
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
id
d50a5da4-c448-4b93-b495-05cedeec1913 (old id 156556)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16724810&dopt=Abstract
date added to LUP
2016-04-01 16:09:58
date last changed
2021-03-22 13:11:43
@inbook{d50a5da4-c448-4b93-b495-05cedeec1913,
  abstract     = {Abstract in Undetermined<br/>It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the complexity behind these diseases can be reduced. The use of linkage analysis and positional cloning of genes in animal models for RA resulted in the identification of one of the genes regulating severity of arthritis in rats and mice, the Ncf1 gene. The Ncf1 gene encodes for the Ncf1 protein that is involved in production of free oxygen radicals through the NADPH oxidase complex, which opens up a new pathway for therapeutic treatment of inflammatory diseases. in most cases, however, a quantitative trait locus (QTL) is the sum effect of several genes within and outside the QTL, which make positional cloning difficult. Here we will discuss the possibilities and difficulties of gene identification in animal models of autoimmune disorders.},
  author       = {Johannesson, Martina and Hultqvist, Malin and Holmdahl, Rikard},
  booktitle    = {Current Concepts in Autoimmunity and Chronic Inflammation (Current Topics in Microbiology and Immunology)},
  isbn         = {978-3-540-29713-0},
  issn         = {0070-217X},
  language     = {eng},
  number       = {305},
  publisher    = {Springer},
  title        = {Genetics of autoimmune diseases: a multistep process.},
  url          = {https://lup.lub.lu.se/search/files/4589256/625455.pdf},
  doi          = {10.1007/3-540-29714-6_13},
  year         = {2006},
}