Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The Influence of Age on Cerebral Tissue Oxygenation in Vasovagal Syncope and Orthostatic Hypotension

Kharraziha, Isabella LU orcid ; Torabi, Parisa LU orcid ; Johansson, Madeleine LU orcid ; Sutton, Richard ; Fedorowski, Artur LU orcid and Hamrefors, Viktor LU orcid (2022) In Journal of Clinical Medicine 11(15). p.1-12
Abstract
Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal... (More)
Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal phase) and during syncope in age groups of <30, 30–60, and >60 years. During the head-up tilt test, cerebral tissue oxygenation at the presyncopal phase decreased with age, both in patients with vasovagal syncope (<30 years: 66.9 ± 6.2, 30–60: 64.5 ± 6.1, >60: 62.2 ± 5.8%; p = 0.009) and orthostatic hypotension (<30: 67.4 ± 4.4, 30–60: 61.6 ± 6.2, >60: 57.5 ± 3.9; p < 0.001). Mean systolic blood pressure at the presyncopal phase did not differ according to age. Cerebral oxygenation prior to syncope in older individuals with vasovagal syncope and orthostatic hypotension is lower compared with younger individuals independently of systolic blood pressure. This suggests that the level of cerebral oxygenation at which syncope is elected is lower in older individuals. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vasovagal syncope, orthostatic hypotension, syncope
in
Journal of Clinical Medicine
volume
11
issue
15
article number
4302
pages
1 - 12
publisher
MDPI AG
external identifiers
  • scopus:85136793470
  • pmid:35893391
ISSN
2077-0383
DOI
10.3390/jcm11154302
language
English
LU publication?
yes
id
15656a00-0370-41dc-9b32-feb1be70d1a0
date added to LUP
2022-07-26 23:43:57
date last changed
2024-02-18 07:17:30
@article{15656a00-0370-41dc-9b32-feb1be70d1a0,
  abstract     = {{Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal phase) and during syncope in age groups of &lt;30, 30–60, and &gt;60 years. During the head-up tilt test, cerebral tissue oxygenation at the presyncopal phase decreased with age, both in patients with vasovagal syncope (&lt;30 years: 66.9 ± 6.2, 30–60: 64.5 ± 6.1, &gt;60: 62.2 ± 5.8%; p = 0.009) and orthostatic hypotension (&lt;30: 67.4 ± 4.4, 30–60: 61.6 ± 6.2, &gt;60: 57.5 ± 3.9; p &lt; 0.001). Mean systolic blood pressure at the presyncopal phase did not differ according to age. Cerebral oxygenation prior to syncope in older individuals with vasovagal syncope and orthostatic hypotension is lower compared with younger individuals independently of systolic blood pressure. This suggests that the level of cerebral oxygenation at which syncope is elected is lower in older individuals.}},
  author       = {{Kharraziha, Isabella and Torabi, Parisa and Johansson, Madeleine and Sutton, Richard and Fedorowski, Artur and Hamrefors, Viktor}},
  issn         = {{2077-0383}},
  keywords     = {{vasovagal syncope; orthostatic hypotension; syncope}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{1--12}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{The Influence of Age on Cerebral Tissue Oxygenation in Vasovagal Syncope and Orthostatic Hypotension}},
  url          = {{http://dx.doi.org/10.3390/jcm11154302}},
  doi          = {{10.3390/jcm11154302}},
  volume       = {{11}},
  year         = {{2022}},
}