The Influence of Age on Cerebral Tissue Oxygenation in Vasovagal Syncope and Orthostatic Hypotension
(2022) In Journal of Clinical Medicine 11(15). p.1-12- Abstract
- Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal... (More)
- Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal phase) and during syncope in age groups of <30, 30–60, and >60 years. During the head-up tilt test, cerebral tissue oxygenation at the presyncopal phase decreased with age, both in patients with vasovagal syncope (<30 years: 66.9 ± 6.2, 30–60: 64.5 ± 6.1, >60: 62.2 ± 5.8%; p = 0.009) and orthostatic hypotension (<30: 67.4 ± 4.4, 30–60: 61.6 ± 6.2, >60: 57.5 ± 3.9; p < 0.001). Mean systolic blood pressure at the presyncopal phase did not differ according to age. Cerebral oxygenation prior to syncope in older individuals with vasovagal syncope and orthostatic hypotension is lower compared with younger individuals independently of systolic blood pressure. This suggests that the level of cerebral oxygenation at which syncope is elected is lower in older individuals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/15656a00-0370-41dc-9b32-feb1be70d1a0
- author
- Kharraziha, Isabella LU ; Torabi, Parisa LU ; Johansson, Madeleine LU ; Sutton, Richard ; Fedorowski, Artur LU and Hamrefors, Viktor LU
- organization
- publishing date
- 2022-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- vasovagal syncope, orthostatic hypotension, syncope
- in
- Journal of Clinical Medicine
- volume
- 11
- issue
- 15
- article number
- 4302
- pages
- 1 - 12
- publisher
- MDPI AG
- external identifiers
-
- scopus:85136793470
- pmid:35893391
- ISSN
- 2077-0383
- DOI
- 10.3390/jcm11154302
- language
- English
- LU publication?
- yes
- id
- 15656a00-0370-41dc-9b32-feb1be70d1a0
- date added to LUP
- 2022-07-26 23:43:57
- date last changed
- 2024-02-18 07:17:30
@article{15656a00-0370-41dc-9b32-feb1be70d1a0, abstract = {{Age-related physiological impairment increases susceptibility to syncope. We tested the hypotheses that cerebral oxygenation during orthostatic provocation, as well as the level at which syncope occurs, differs according to age. Non-invasive hemodynamic monitoring and cerebral oximetry were applied during a head-up tilt test in 139 patients with vasovagal syncope (mean (SD) 45, (17) years, 60%-female); 121 patients with orthostatic hypotension (61.4 (19.2) years, 49.6%-female); and 82 patients with a negative head-up tilt test (45 (18) years, 61%-female). Group differences in cerebral tissue oxygenation levels and systolic blood pressure were assessed in supine at 3 and 10 min of orthostatic provocation, 30 s before (i.e., presyncopal phase) and during syncope in age groups of <30, 30–60, and >60 years. During the head-up tilt test, cerebral tissue oxygenation at the presyncopal phase decreased with age, both in patients with vasovagal syncope (<30 years: 66.9 ± 6.2, 30–60: 64.5 ± 6.1, >60: 62.2 ± 5.8%; p = 0.009) and orthostatic hypotension (<30: 67.4 ± 4.4, 30–60: 61.6 ± 6.2, >60: 57.5 ± 3.9; p < 0.001). Mean systolic blood pressure at the presyncopal phase did not differ according to age. Cerebral oxygenation prior to syncope in older individuals with vasovagal syncope and orthostatic hypotension is lower compared with younger individuals independently of systolic blood pressure. This suggests that the level of cerebral oxygenation at which syncope is elected is lower in older individuals.}}, author = {{Kharraziha, Isabella and Torabi, Parisa and Johansson, Madeleine and Sutton, Richard and Fedorowski, Artur and Hamrefors, Viktor}}, issn = {{2077-0383}}, keywords = {{vasovagal syncope; orthostatic hypotension; syncope}}, language = {{eng}}, number = {{15}}, pages = {{1--12}}, publisher = {{MDPI AG}}, series = {{Journal of Clinical Medicine}}, title = {{The Influence of Age on Cerebral Tissue Oxygenation in Vasovagal Syncope and Orthostatic Hypotension}}, url = {{http://dx.doi.org/10.3390/jcm11154302}}, doi = {{10.3390/jcm11154302}}, volume = {{11}}, year = {{2022}}, }