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Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes.

Paulsson, Kajsa LU and Johansson, Bertil LU (2007) In Pathologie et Biologie 55(1). p.37-48
Abstract
Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sole, trisomy 8, acute myeloid leukemia, chromosomal aberration, myelodysplastic syndrome
in
Pathologie et Biologie
volume
55
issue
1
pages
37 - 48
publisher
Elsevier
external identifiers
  • wos:000244914600005
  • scopus:33846853947
ISSN
0369-8114
DOI
10.1016/j.patbio.2006.04.007
language
English
LU publication?
yes
id
1d401e8c-b879-476a-8b61-45cc69fe4992 (old id 156811)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16697122&dopt=Abstract
date added to LUP
2007-07-09 10:54:51
date last changed
2017-10-08 04:09:59
@article{1d401e8c-b879-476a-8b61-45cc69fe4992,
  abstract     = {Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abnormalities, cell of origin, and functional and pathogenetic consequences. Here, we summarize and review these various aspects of trisomy 8, focusing on AMLs and MDS harboring this abnormality as a single change.},
  author       = {Paulsson, Kajsa and Johansson, Bertil},
  issn         = {0369-8114},
  keyword      = {sole,trisomy 8,acute myeloid leukemia,chromosomal aberration,myelodysplastic syndrome},
  language     = {eng},
  number       = {1},
  pages        = {37--48},
  publisher    = {Elsevier},
  series       = {Pathologie et Biologie},
  title        = {Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes.},
  url          = {http://dx.doi.org/10.1016/j.patbio.2006.04.007},
  volume       = {55},
  year         = {2007},
}