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Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens

Bober, Marta LU ; Enochsson, Charlotte ; Collin, Mattias LU orcid and Mörgelin, Matthias LU (2010) In Journal of Innate Immunity 2(2). p.160-166
Abstract
Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to... (More)
Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to Collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for Collagen VI in host-pathogen interplay during respiratory tract infection. Copyright (C) 2009 S. Karger AG, Basel (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Respiratory infection, adhesion, Primary, Host-pathogen interaction, Collagen VI, Adhesin, Airways, Respiratory pathogen, Streptococcus
in
Journal of Innate Immunity
volume
2
issue
2
pages
160 - 166
publisher
Karger
external identifiers
  • wos:000274768800007
  • pmid:20375633
  • scopus:77953459012
  • pmid:20375633
ISSN
1662-811X
DOI
10.1159/000232587
language
English
LU publication?
yes
id
bc227f9b-35ba-4778-9649-4ff57196073d (old id 1568567)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20375633?dopt=Abstract
date added to LUP
2016-04-01 10:51:04
date last changed
2022-04-12 18:13:03
@article{bc227f9b-35ba-4778-9649-4ff57196073d,
  abstract     = {{Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to Collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for Collagen VI in host-pathogen interplay during respiratory tract infection. Copyright (C) 2009 S. Karger AG, Basel}},
  author       = {{Bober, Marta and Enochsson, Charlotte and Collin, Mattias and Mörgelin, Matthias}},
  issn         = {{1662-811X}},
  keywords     = {{Respiratory infection; adhesion; Primary; Host-pathogen interaction; Collagen VI; Adhesin; Airways; Respiratory pathogen; Streptococcus}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{160--166}},
  publisher    = {{Karger}},
  series       = {{Journal of Innate Immunity}},
  title        = {{Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens}},
  url          = {{http://dx.doi.org/10.1159/000232587}},
  doi          = {{10.1159/000232587}},
  volume       = {{2}},
  year         = {{2010}},
}