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The incidence of spina bifida in Sweden 1973-2003: the effect of prenatal diagnosis.

Nikkilä, Annamari LU ; Rydhstrom, Hakan and Källén, Bengt LU (2006) In European Journal of Public Health 16(6). p.660-662
Abstract
Background: Many studies have been conducted on the accuracy of prenatal ultrasound diagnosis of foetal CNS-malformations. These studies were mostly hospital-based or, sometimes, multicentre studies. We present here a population-based study of the prenatal diagnosis of spina bifida in Sweden over a period of 31 years. Methods: We compared the number of newborns with spina bifida and the elective terminations because of the prenatal diagnosis of spina bifida for different periods. Results: The rate of spina bifida among newborns diminished gradually from 0.55 per 1000 to 0.29 per 1000 during the study period. In M county the rate of spina bifida at birth decreased very rapidly and from 1993 onwards was about half of that in the rest of the... (More)
Background: Many studies have been conducted on the accuracy of prenatal ultrasound diagnosis of foetal CNS-malformations. These studies were mostly hospital-based or, sometimes, multicentre studies. We present here a population-based study of the prenatal diagnosis of spina bifida in Sweden over a period of 31 years. Methods: We compared the number of newborns with spina bifida and the elective terminations because of the prenatal diagnosis of spina bifida for different periods. Results: The rate of spina bifida among newborns diminished gradually from 0.55 per 1000 to 0.29 per 1000 during the study period. In M county the rate of spina bifida at birth decreased very rapidly and from 1993 onwards was about half of that in the rest of the country. Conclusion: There has been a decline in the rate of spina bifida at birth. This decline can be seen earlier in the southern part of the country, M county. The decline is probably, to a great extent, a consequence of prenatal ultrasound screening. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
ultrasound screening, spina bifida, prenatal diagnosis
in
European Journal of Public Health
volume
16
issue
6
pages
660 - 662
publisher
Oxford University Press
external identifiers
  • wos:000242472500019
  • scopus:33845453794
  • pmid:16672253
ISSN
1101-1262
DOI
10.1093/eurpub/ckl053
language
English
LU publication?
yes
id
a5419c1e-0ed7-46e6-a377-53d85511fd05 (old id 157070)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16672253&dopt=Abstract
date added to LUP
2016-04-01 12:08:11
date last changed
2021-02-17 04:33:48
@article{a5419c1e-0ed7-46e6-a377-53d85511fd05,
  abstract     = {Background: Many studies have been conducted on the accuracy of prenatal ultrasound diagnosis of foetal CNS-malformations. These studies were mostly hospital-based or, sometimes, multicentre studies. We present here a population-based study of the prenatal diagnosis of spina bifida in Sweden over a period of 31 years. Methods: We compared the number of newborns with spina bifida and the elective terminations because of the prenatal diagnosis of spina bifida for different periods. Results: The rate of spina bifida among newborns diminished gradually from 0.55 per 1000 to 0.29 per 1000 during the study period. In M county the rate of spina bifida at birth decreased very rapidly and from 1993 onwards was about half of that in the rest of the country. Conclusion: There has been a decline in the rate of spina bifida at birth. This decline can be seen earlier in the southern part of the country, M county. The decline is probably, to a great extent, a consequence of prenatal ultrasound screening.},
  author       = {Nikkilä, Annamari and Rydhstrom, Hakan and Källén, Bengt},
  issn         = {1101-1262},
  language     = {eng},
  number       = {6},
  pages        = {660--662},
  publisher    = {Oxford University Press},
  series       = {European Journal of Public Health},
  title        = {The incidence of spina bifida in Sweden 1973-2003: the effect of prenatal diagnosis.},
  url          = {http://dx.doi.org/10.1093/eurpub/ckl053},
  doi          = {10.1093/eurpub/ckl053},
  volume       = {16},
  year         = {2006},
}