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Titanium dioxide nanotubes enhance bone bonding in vivo

Bjursten, Lars Magnus LU ; Rasmusson, Lars; Oh, Seunghan; Smith, Garrett LU ; Brammer, Karla S. and Jin, Sungho (2010) In Journal of Biomedical Materials Research. Part A 92A(3). p.1218-1224
Abstract
Implant topography is critical to the clinical Success of bone-anchored implants, yet little is known how nano-modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surface: titanium dioxide (TiO2) nanotubes and TiO2 gritblasted surfaces. In previous in vitro studies, the topography of the TiO2 nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium Surfaces. After four weeks of implantation in rabbit tibias, pull-out testing indicated that TiO2 nanotubes significantly improved bone bonding strength by as much as nine-fold compared with TiO2 gritblasted surfaces. Histological analysis confirmed greater bone-implant contact area, new bone... (More)
Implant topography is critical to the clinical Success of bone-anchored implants, yet little is known how nano-modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surface: titanium dioxide (TiO2) nanotubes and TiO2 gritblasted surfaces. In previous in vitro studies, the topography of the TiO2 nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium Surfaces. After four weeks of implantation in rabbit tibias, pull-out testing indicated that TiO2 nanotubes significantly improved bone bonding strength by as much as nine-fold compared with TiO2 gritblasted surfaces. Histological analysis confirmed greater bone-implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength. (C) 2009 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
histology, strength, mechanical, osseointegration, titanium dioxide nanotube, bone implant
in
Journal of Biomedical Materials Research. Part A
volume
92A
issue
3
pages
1218 - 1224
publisher
John Wiley & Sons
external identifiers
  • wos:000274307600043
  • scopus:75749148812
ISSN
1552-4965
DOI
10.1002/jbm.a.32463
language
English
LU publication?
yes
id
ff0b28f9-c274-42d9-be94-50bce56e4982 (old id 1570700)
date added to LUP
2010-03-17 08:34:25
date last changed
2018-07-15 03:03:03
@article{ff0b28f9-c274-42d9-be94-50bce56e4982,
  abstract     = {Implant topography is critical to the clinical Success of bone-anchored implants, yet little is known how nano-modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surface: titanium dioxide (TiO2) nanotubes and TiO2 gritblasted surfaces. In previous in vitro studies, the topography of the TiO2 nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium Surfaces. After four weeks of implantation in rabbit tibias, pull-out testing indicated that TiO2 nanotubes significantly improved bone bonding strength by as much as nine-fold compared with TiO2 gritblasted surfaces. Histological analysis confirmed greater bone-implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength. (C) 2009 Wiley Periodicals, Inc.},
  author       = {Bjursten, Lars Magnus and Rasmusson, Lars and Oh, Seunghan and Smith, Garrett and Brammer, Karla S. and Jin, Sungho},
  issn         = {1552-4965},
  keyword      = {histology,strength,mechanical,osseointegration,titanium dioxide nanotube,bone implant},
  language     = {eng},
  number       = {3},
  pages        = {1218--1224},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biomedical Materials Research. Part A},
  title        = {Titanium dioxide nanotubes enhance bone bonding in vivo},
  url          = {http://dx.doi.org/10.1002/jbm.a.32463},
  volume       = {92A},
  year         = {2010},
}