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Drug transport in responding lipid membranes can be regulated by an external osmotic gradient

Costa, Fatima LU ; Åberg, Christoffer LU ; Sousa, J J S and Sparr, Emma LU (2005) In Langmuir 21(23). p.10307-10310
Abstract
In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
21
issue
23
pages
10307 - 10310
publisher
The American Chemical Society
external identifiers
  • wos:000233129500014
  • scopus:28044459214
ISSN
0743-7463
DOI
10.1021/la051947n
language
English
LU publication?
yes
id
a6aef334-9996-4a7c-a399-2403113ca723 (old id 157303)
date added to LUP
2007-07-11 09:17:22
date last changed
2017-01-01 04:26:58
@article{a6aef334-9996-4a7c-a399-2403113ca723,
  abstract     = {In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.},
  author       = {Costa, Fatima and Åberg, Christoffer and Sousa, J J S and Sparr, Emma},
  issn         = {0743-7463},
  language     = {eng},
  number       = {23},
  pages        = {10307--10310},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {Drug transport in responding lipid membranes can be regulated by an external osmotic gradient},
  url          = {http://dx.doi.org/10.1021/la051947n},
  volume       = {21},
  year         = {2005},
}