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Fengycin interaction with lipid monolayers at the air-aqueous interface - implications for the effect of fengycin on biological membranes

Deleu, Magali LU ; Paquot, M and Nylander, Tommy LU (2005) In Journal of Colloid and Interface Science 283(2). p.358-365
Abstract
In this study, we investigated the interaction of fengycin, a lipopeptide produced by Bacillus subtilis, with lipid monolayers using the Langmuir trough technique in combination with Brewster angle rnicroscopy. Thermodynamic analyses were performed to get further information about the mixing behavior and the molecular interactions between the two components. The effect of fengycin on the structural and morphological characteristics of DPPC monolayers, as a simple model of biological membranes, depends on the fengycin molar ratio. With a small proportion of fengycin (X-f less than or equal to 0.1), the compressibility of the monolayer is modified but the morphological characteristics of the DPPC are not significantly affected. At an... (More)
In this study, we investigated the interaction of fengycin, a lipopeptide produced by Bacillus subtilis, with lipid monolayers using the Langmuir trough technique in combination with Brewster angle rnicroscopy. Thermodynamic analyses were performed to get further information about the mixing behavior and the molecular interactions between the two components. The effect of fengycin on the structural and morphological characteristics of DPPC monolayers, as a simple model of biological membranes, depends on the fengycin molar ratio. With a small proportion of fengycin (X-f less than or equal to 0.1), the compressibility of the monolayer is modified but the morphological characteristics of the DPPC are not significantly affected. At an intermediate molar ratio (0.1 < X-f less than or equal to 0.5), fengycin has a fluidizing effect on the DPPC monolayer by interacting partially with DPPC molecules. At higher molar ratio (X-f = 0.66), fengycin totally dissolves the ordered phase of the lipid. These results highlight the capacity of fengycin to perturb the DPPC organization and are discussed in relation to fengycin capacity to affect biological membranes. (C) 2004 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Colloid and Interface Science
volume
283
issue
2
pages
358 - 365
publisher
Elsevier
external identifiers
  • wos:000227393300010
  • pmid:15721905
  • scopus:13944279526
ISSN
1095-7103
DOI
10.1016/j.jcis.2004.09.036
language
English
LU publication?
yes
id
a03e561b-67ea-45e4-9172-8893394add8a (old id 157309)
date added to LUP
2007-07-11 09:26:05
date last changed
2017-07-30 03:48:15
@article{a03e561b-67ea-45e4-9172-8893394add8a,
  abstract     = {In this study, we investigated the interaction of fengycin, a lipopeptide produced by Bacillus subtilis, with lipid monolayers using the Langmuir trough technique in combination with Brewster angle rnicroscopy. Thermodynamic analyses were performed to get further information about the mixing behavior and the molecular interactions between the two components. The effect of fengycin on the structural and morphological characteristics of DPPC monolayers, as a simple model of biological membranes, depends on the fengycin molar ratio. With a small proportion of fengycin (X-f less than or equal to 0.1), the compressibility of the monolayer is modified but the morphological characteristics of the DPPC are not significantly affected. At an intermediate molar ratio (0.1 &lt; X-f less than or equal to 0.5), fengycin has a fluidizing effect on the DPPC monolayer by interacting partially with DPPC molecules. At higher molar ratio (X-f = 0.66), fengycin totally dissolves the ordered phase of the lipid. These results highlight the capacity of fengycin to perturb the DPPC organization and are discussed in relation to fengycin capacity to affect biological membranes. (C) 2004 Elsevier Inc. All rights reserved.},
  author       = {Deleu, Magali and Paquot, M and Nylander, Tommy},
  issn         = {1095-7103},
  language     = {eng},
  number       = {2},
  pages        = {358--365},
  publisher    = {Elsevier},
  series       = {Journal of Colloid and Interface Science},
  title        = {Fengycin interaction with lipid monolayers at the air-aqueous interface - implications for the effect of fengycin on biological membranes},
  url          = {http://dx.doi.org/10.1016/j.jcis.2004.09.036},
  volume       = {283},
  year         = {2005},
}