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Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)

Körner, Anna LU ; Larsson, A; Piculell, Lennart LU and Wittgren, B (2005) In The Journal of Physical Chemistry Part B 109(23). p.11530-11537
Abstract
A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the... (More)
A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
109
issue
23
pages
11530 - 11537
publisher
The American Chemical Society
external identifiers
  • wos:000229751800020
  • scopus:21644452768
ISSN
1520-5207
DOI
10.1021/jp044332s
language
English
LU publication?
yes
id
0f539163-297f-4759-9f1f-c23633dc8b9b (old id 157428)
date added to LUP
2007-07-11 14:53:33
date last changed
2017-08-20 04:16:59
@article{0f539163-297f-4759-9f1f-c23633dc8b9b,
  abstract     = {A systematic study of the dissolution of dry, polydisperse polyethylene oxide) (PEO) samples, obtained from mixtures of low-molecular-weight and high-molecular-weight PEO, was made. During the dissolution process, the individual release of the low-and high-molecular-weight fractions was monitored. The highmolecular-weight/low-molecular-weight ratio controls the release rate, and the fraction of high-molecular-weight polymers dominates the effect on the overall release rate in mixed PEO tablets. Both fractions are released at the same rate during the main part of the dissolution process; however, during the initial dissolution period a fractionation occurs. The release rate is not a unique function of the average molecular weight of the polymer, but also depends on the polydispersity. By contrast, the average dimension of a polymer coil, as given by the intrinsic viscosity, gives a good prediction of the release rate irrespective of the polydispersity or details of the molecular weight distribution.},
  author       = {Körner, Anna and Larsson, A and Piculell, Lennart and Wittgren, B},
  issn         = {1520-5207},
  language     = {eng},
  number       = {23},
  pages        = {11530--11537},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Part B},
  title        = {Molecular information on the dissolution of polydisperse polymers: Mixtures of long and short poly(ethylene oxide)},
  url          = {http://dx.doi.org/10.1021/jp044332s},
  volume       = {109},
  year         = {2005},
}