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Tuning the polymer release from hydrophilic matrix tablets by mixing short and long matrix polymers

Körner, Anna LU ; Larsson, A; Piculell, Lennart LU and Wittgren, B (2005) In Journal of Pharmaceutical Sciences 94(4). p.759-769
Abstract
In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so that the effect of tablet heterogeneity could be assessed, but also by purifying the original powders so the effect of additives could be determined. When the mixed tablet was dominated by the lowmolecular weight fraction, a faster dissolution was observed for the tablet mixed at the powder level. In those cases small gel pieces were released from... (More)
In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so that the effect of tablet heterogeneity could be assessed, but also by purifying the original powders so the effect of additives could be determined. When the mixed tablet was dominated by the lowmolecular weight fraction, a faster dissolution was observed for the tablet mixed at the powder level. In those cases small gel pieces were released from the tablet during the whole dissolution process. As long as no gel piece erosion was observed, it did not matter if the two polymer fractions were blended on the molecular level or on the powder level, the steady-state dissolution rate was the same. The presence of small amounts of additives in the nonpurified commercial samples had no significant effect on the tablet dissolution within the uncertainty of the experiment. (c) 2005 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pharmaceutical Sciences
volume
94
issue
4
pages
759 - 769
publisher
John Wiley & Sons
external identifiers
  • wos:000228150400006
  • pmid:15723282
  • scopus:17744396350
ISSN
0022-3549
DOI
10.1002/jps.20288
language
English
LU publication?
yes
id
b03e8a88-a004-4ccf-880e-b3b9a09df032 (old id 157434)
date added to LUP
2007-07-11 14:55:06
date last changed
2017-05-14 03:35:49
@article{b03e8a88-a004-4ccf-880e-b3b9a09df032,
  abstract     = {In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so that the effect of tablet heterogeneity could be assessed, but also by purifying the original powders so the effect of additives could be determined. When the mixed tablet was dominated by the lowmolecular weight fraction, a faster dissolution was observed for the tablet mixed at the powder level. In those cases small gel pieces were released from the tablet during the whole dissolution process. As long as no gel piece erosion was observed, it did not matter if the two polymer fractions were blended on the molecular level or on the powder level, the steady-state dissolution rate was the same. The presence of small amounts of additives in the nonpurified commercial samples had no significant effect on the tablet dissolution within the uncertainty of the experiment. (c) 2005 Wiley-Liss, Inc.},
  author       = {Körner, Anna and Larsson, A and Piculell, Lennart and Wittgren, B},
  issn         = {0022-3549},
  language     = {eng},
  number       = {4},
  pages        = {759--769},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pharmaceutical Sciences},
  title        = {Tuning the polymer release from hydrophilic matrix tablets by mixing short and long matrix polymers},
  url          = {http://dx.doi.org/10.1002/jps.20288},
  volume       = {94},
  year         = {2005},
}