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Physicochemical characterization of PEG1500-12-acyloxy-stearate micelles and liquid crystalline phases

McNamee, Cathy LU ; Nilsson, Markus LU ; von Corswant, C and Söderman, Olle LU (2005) In Langmuir 21(18). p.8146-8154
Abstract
PEG 12-acyloxy-stearates are used as drug delivery carriers that have low cell damage effects. The mechanical and physical properties surrounding these processes and surfactants are still however not known. In this study, the physicochemical micellar properties of PEG 12-acyloxy-stearates were characterized by optical microscopic, nuclear magnetic resonance, and small-angle X-ray scattering techniques. We determined the phase diagrams of the surfactants as a function of surfactant concentration and temperature, the micellar size and shape, and micellar dynamics. We found that each surfactant has a micellar, cubic Im3m, and hexagonal phase. The aggregation number in the discrete cubic phase, as determined by small-angle X-ray scattering,... (More)
PEG 12-acyloxy-stearates are used as drug delivery carriers that have low cell damage effects. The mechanical and physical properties surrounding these processes and surfactants are still however not known. In this study, the physicochemical micellar properties of PEG 12-acyloxy-stearates were characterized by optical microscopic, nuclear magnetic resonance, and small-angle X-ray scattering techniques. We determined the phase diagrams of the surfactants as a function of surfactant concentration and temperature, the micellar size and shape, and micellar dynamics. We found that each surfactant has a micellar, cubic Im3m, and hexagonal phase. The aggregation number in the discrete cubic phase, as determined by small-angle X-ray scattering, was approximately 150 for each surfactant, and showed no measurable chain-length dependence. The diffusion coefficients of the surfactant showed a discontinuity between the micellar and cubic phases, where the cubic phases gave very low values on the order of 10(-16) m(2) s(-1): this value indicates a non-bicontinuous cubic structure. In summary, these surfactants behave to a large extent as nonionic poly(ethylene glycol) surfactants with extended PEG headgroups. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
21
issue
18
pages
8146 - 8154
publisher
The American Chemical Society
external identifiers
  • wos:000231550000013
  • scopus:24944543854
ISSN
0743-7463
DOI
10.1021/la0511539
language
English
LU publication?
yes
id
ad822ab6-05bb-414d-881c-f854006d085a (old id 157487)
date added to LUP
2007-07-11 16:28:40
date last changed
2017-01-01 04:57:51
@article{ad822ab6-05bb-414d-881c-f854006d085a,
  abstract     = {PEG 12-acyloxy-stearates are used as drug delivery carriers that have low cell damage effects. The mechanical and physical properties surrounding these processes and surfactants are still however not known. In this study, the physicochemical micellar properties of PEG 12-acyloxy-stearates were characterized by optical microscopic, nuclear magnetic resonance, and small-angle X-ray scattering techniques. We determined the phase diagrams of the surfactants as a function of surfactant concentration and temperature, the micellar size and shape, and micellar dynamics. We found that each surfactant has a micellar, cubic Im3m, and hexagonal phase. The aggregation number in the discrete cubic phase, as determined by small-angle X-ray scattering, was approximately 150 for each surfactant, and showed no measurable chain-length dependence. The diffusion coefficients of the surfactant showed a discontinuity between the micellar and cubic phases, where the cubic phases gave very low values on the order of 10(-16) m(2) s(-1): this value indicates a non-bicontinuous cubic structure. In summary, these surfactants behave to a large extent as nonionic poly(ethylene glycol) surfactants with extended PEG headgroups.},
  author       = {McNamee, Cathy and Nilsson, Markus and von Corswant, C and Söderman, Olle},
  issn         = {0743-7463},
  language     = {eng},
  number       = {18},
  pages        = {8146--8154},
  publisher    = {The American Chemical Society},
  series       = {Langmuir},
  title        = {Physicochemical characterization of PEG1500-12-acyloxy-stearate micelles and liquid crystalline phases},
  url          = {http://dx.doi.org/10.1021/la0511539},
  volume       = {21},
  year         = {2005},
}