An easy-to-use method for detecting fetal hemoglobin-A test to identify bleeding from vasa previa.
(2006) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 131(2). p.151-153- Abstract
- Background: Vasa previa is a rare but potentially dangerous fetal condition that may occur during pregnancy. Ideally, all cases such cases are detected antenatally, but many present as late vaginal hemorrhaging. At the current time, there is no test for fetal hemoglobin (HbF) in general use. Methods: A modified method of identifying HbF is presented. Five milliliters of 0.14 M NaOH was combined with 50 mu l of a mixture of fetal and maternal blood. After 2 min, it was judged if the solution still had a red tone or not. The sensitivity of this method for detecting HbF was assessed. Results: All 15 clinical personnel could identify both 69% and 34% HbF mixed with adult hemoglobin (100% sensitivity), 14 out of 15 could identify 17% HbF (93%... (More)
- Background: Vasa previa is a rare but potentially dangerous fetal condition that may occur during pregnancy. Ideally, all cases such cases are detected antenatally, but many present as late vaginal hemorrhaging. At the current time, there is no test for fetal hemoglobin (HbF) in general use. Methods: A modified method of identifying HbF is presented. Five milliliters of 0.14 M NaOH was combined with 50 mu l of a mixture of fetal and maternal blood. After 2 min, it was judged if the solution still had a red tone or not. The sensitivity of this method for detecting HbF was assessed. Results: All 15 clinical personnel could identify both 69% and 34% HbF mixed with adult hemoglobin (100% sensitivity), 14 out of 15 could identify 17% HbF (93% sensitivity), and 12 out of 15 could identify a mixture containing 8% HbF (80% sensitivity). Conclusion: Our rapid. simple test for HbF was at least as sensitive as slower, more cumbersome alkali denaturation tests in common use. It could prove to be a lifesaving toot in ruling out vasa previa bleeding in cases of unclear late pregnancy hemorrhages. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/158132
- author
- Lindqvist, Pelle LU and Gren, Peter
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Obstetrics, Gynecology, and Reproductive Biology
- volume
- 131
- issue
- 2
- pages
- 151 - 153
- publisher
- Elsevier
- external identifiers
-
- scopus:33947397193
- pmid:16797824
- ISSN
- 0301-2115
- DOI
- 10.1016/j.ejogrb.2006.05.011
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 4c4df69b-f402-40af-a2cc-f4df3ae8d4e2 (old id 158132)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16797824&dopt=Abstract
- date added to LUP
- 2016-04-01 12:14:12
- date last changed
- 2022-03-28 22:07:50
@article{4c4df69b-f402-40af-a2cc-f4df3ae8d4e2,
abstract = {{Background: Vasa previa is a rare but potentially dangerous fetal condition that may occur during pregnancy. Ideally, all cases such cases are detected antenatally, but many present as late vaginal hemorrhaging. At the current time, there is no test for fetal hemoglobin (HbF) in general use. Methods: A modified method of identifying HbF is presented. Five milliliters of 0.14 M NaOH was combined with 50 mu l of a mixture of fetal and maternal blood. After 2 min, it was judged if the solution still had a red tone or not. The sensitivity of this method for detecting HbF was assessed. Results: All 15 clinical personnel could identify both 69% and 34% HbF mixed with adult hemoglobin (100% sensitivity), 14 out of 15 could identify 17% HbF (93% sensitivity), and 12 out of 15 could identify a mixture containing 8% HbF (80% sensitivity). Conclusion: Our rapid. simple test for HbF was at least as sensitive as slower, more cumbersome alkali denaturation tests in common use. It could prove to be a lifesaving toot in ruling out vasa previa bleeding in cases of unclear late pregnancy hemorrhages.}},
author = {{Lindqvist, Pelle and Gren, Peter}},
issn = {{0301-2115}},
language = {{eng}},
number = {{2}},
pages = {{151--153}},
publisher = {{Elsevier}},
series = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}},
title = {{An easy-to-use method for detecting fetal hemoglobin-A test to identify bleeding from vasa previa.}},
url = {{https://lup.lub.lu.se/search/files/2839568/1059988.pdf}},
doi = {{10.1016/j.ejogrb.2006.05.011}},
volume = {{131}},
year = {{2006}},
}