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Exercise-induced release of cytokines in patients with major depressive disorder.

Hallberg, Ludvig LU ; Janelidze, Shorena LU ; Engström, Gunnar LU ; Wisén, Anita LU ; Westrin, Åsa LU and Brundin, Lena LU (2010) In Journal of Affective Disorders Apr 8. p.262-267
Abstract
BACKGROUND: Patients with major depressive disorder (MDD) may display elevated plasma levels of pro-inflammatory substances. Although the underlying mechanisms are unknown, inflammation has been proposed to play a direct role in the generation of depressive symptoms. Skeletal muscle is a potent producer of cytokines, and physical exercise has been suggested to alleviate symptoms of depression. In this study we therefore addressed the question of whether MDD patients display altered levels of pro-, anti-inflammatory and regulatory factors in the blood in response to acute exercise. METHODS: Eighteen MDD patients and 18 healthy controls performed a maximal-workload exercise challenge. Blood samples were taken before the test, at sub-maximal... (More)
BACKGROUND: Patients with major depressive disorder (MDD) may display elevated plasma levels of pro-inflammatory substances. Although the underlying mechanisms are unknown, inflammation has been proposed to play a direct role in the generation of depressive symptoms. Skeletal muscle is a potent producer of cytokines, and physical exercise has been suggested to alleviate symptoms of depression. In this study we therefore addressed the question of whether MDD patients display altered levels of pro-, anti-inflammatory and regulatory factors in the blood in response to acute exercise. METHODS: Eighteen MDD patients and 18 healthy controls performed a maximal-workload exercise challenge. Blood samples were taken before the test, at sub-maximal and maximal workload, as well as 30 and 60min after testing. The plasma levels of SAA, TNF-alpha, S-VCAM, S-ICAM, CRP, IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 and IL-13 were assayed using multiplex sandwich ELISA. RESULTS: Exercise-induced significant changes in the plasma levels of inflammatory substances in both MDD patients and controls. IL-8, IL-6 and TNF-alpha increased, and IL-4 decreased during the challenge in both groups. In addition, IFN-gamma decreased in the controls. There was a significant difference in IL-6 reactivity between the groups at the sub-max timepoint. LIMITATIONS: Group sizes are comparably limited. CONCLUSION: Exercise induces changes in the blood levels of cytokines in unmedicated MDD patients. Whether these changes affect symptoms of depression should be evaluated in long-term studies of the anti-depressive effects of exercise. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Affective Disorders
volume
Apr 8
pages
262 - 267
publisher
Elsevier
external identifiers
  • wos:000282488000034
  • pmid:20347489
  • scopus:77956264740
ISSN
1573-2517
DOI
10.1016/j.jad.2010.02.133
language
English
LU publication?
yes
id
8bf48c28-27f7-478c-b86f-5ce7d47fe629 (old id 1581525)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20347489?dopt=Abstract
date added to LUP
2010-04-08 15:55:34
date last changed
2018-05-29 09:42:40
@article{8bf48c28-27f7-478c-b86f-5ce7d47fe629,
  abstract     = {BACKGROUND: Patients with major depressive disorder (MDD) may display elevated plasma levels of pro-inflammatory substances. Although the underlying mechanisms are unknown, inflammation has been proposed to play a direct role in the generation of depressive symptoms. Skeletal muscle is a potent producer of cytokines, and physical exercise has been suggested to alleviate symptoms of depression. In this study we therefore addressed the question of whether MDD patients display altered levels of pro-, anti-inflammatory and regulatory factors in the blood in response to acute exercise. METHODS: Eighteen MDD patients and 18 healthy controls performed a maximal-workload exercise challenge. Blood samples were taken before the test, at sub-maximal and maximal workload, as well as 30 and 60min after testing. The plasma levels of SAA, TNF-alpha, S-VCAM, S-ICAM, CRP, IFN-gamma, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12 and IL-13 were assayed using multiplex sandwich ELISA. RESULTS: Exercise-induced significant changes in the plasma levels of inflammatory substances in both MDD patients and controls. IL-8, IL-6 and TNF-alpha increased, and IL-4 decreased during the challenge in both groups. In addition, IFN-gamma decreased in the controls. There was a significant difference in IL-6 reactivity between the groups at the sub-max timepoint. LIMITATIONS: Group sizes are comparably limited. CONCLUSION: Exercise induces changes in the blood levels of cytokines in unmedicated MDD patients. Whether these changes affect symptoms of depression should be evaluated in long-term studies of the anti-depressive effects of exercise.},
  author       = {Hallberg, Ludvig and Janelidze, Shorena and Engström, Gunnar and Wisén, Anita and Westrin, Åsa and Brundin, Lena},
  issn         = {1573-2517},
  language     = {eng},
  pages        = {262--267},
  publisher    = {Elsevier},
  series       = {Journal of Affective Disorders},
  title        = {Exercise-induced release of cytokines in patients with major depressive disorder.},
  url          = {http://dx.doi.org/10.1016/j.jad.2010.02.133},
  volume       = {Apr 8},
  year         = {2010},
}