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Covariation of plasma ghrelin and motilin in irritable bowel syndrome.

Sjölund, Kristina LU ; Ekman, Rolf and Wierup, Nils LU (2010) In Peptides 31. p.1109-1112
Abstract
We have previously shown that ghrelin is mainly localized to the stomach but also occurs, together with the prokinetic hormone motilin, in endocrine cells in the proximal small intestine. This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghrelin is changed in patients with irritable bowel syndrome (IBS). Nine patients with severe IBS and 10 healthy subjects underwent stationary antro-duodeni-jejunal manometry; blood was sampled during similar motility phases in the two groups. The motility phases were monitored and blood samples were collected during fasting and after food intake. Plasma was analyzed for two forms of ghrelin (octanylated and desoctanylated) as well... (More)
We have previously shown that ghrelin is mainly localized to the stomach but also occurs, together with the prokinetic hormone motilin, in endocrine cells in the proximal small intestine. This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghrelin is changed in patients with irritable bowel syndrome (IBS). Nine patients with severe IBS and 10 healthy subjects underwent stationary antro-duodeni-jejunal manometry; blood was sampled during similar motility phases in the two groups. The motility phases were monitored and blood samples were collected during fasting and after food intake. Plasma was analyzed for two forms of ghrelin (octanylated and desoctanylated) as well as for motilin. In IBS patients circulating motilin levels covaried with total ghrelin levels (r=0.90; p<0.004), octanylated ghrelin (r=0.77; p<0.02) and desoctanylated ghrelin (r=0.69; p<0.04). No such correlations were seen in the control group. Octanylated ghrelin comprised 35.3+/-3.9% (mean+/-SEM) of the total circulating ghrelin in the IBS patients compared to 40.4+/-4.5% (mean+/-SEM) in the control group (NS). Ghrelin covaried with motilin in plasma in IBS but not in plasma from healthy subjects. This suggests the two peptides act together in IBS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Peptides
volume
31
pages
1109 - 1112
publisher
Elsevier
external identifiers
  • wos:000283939000016
  • pmid:20338210
  • scopus:77952103939
ISSN
1873-5169
DOI
10.1016/j.peptides.2010.03.021
language
English
LU publication?
yes
id
f72e57b5-48c7-499f-bbe8-644d854468a1 (old id 1581627)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20338210?dopt=Abstract
date added to LUP
2010-04-07 14:05:43
date last changed
2018-05-29 10:37:08
@article{f72e57b5-48c7-499f-bbe8-644d854468a1,
  abstract     = {We have previously shown that ghrelin is mainly localized to the stomach but also occurs, together with the prokinetic hormone motilin, in endocrine cells in the proximal small intestine. This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghrelin is changed in patients with irritable bowel syndrome (IBS). Nine patients with severe IBS and 10 healthy subjects underwent stationary antro-duodeni-jejunal manometry; blood was sampled during similar motility phases in the two groups. The motility phases were monitored and blood samples were collected during fasting and after food intake. Plasma was analyzed for two forms of ghrelin (octanylated and desoctanylated) as well as for motilin. In IBS patients circulating motilin levels covaried with total ghrelin levels (r=0.90; p&lt;0.004), octanylated ghrelin (r=0.77; p&lt;0.02) and desoctanylated ghrelin (r=0.69; p&lt;0.04). No such correlations were seen in the control group. Octanylated ghrelin comprised 35.3+/-3.9% (mean+/-SEM) of the total circulating ghrelin in the IBS patients compared to 40.4+/-4.5% (mean+/-SEM) in the control group (NS). Ghrelin covaried with motilin in plasma in IBS but not in plasma from healthy subjects. This suggests the two peptides act together in IBS.},
  author       = {Sjölund, Kristina and Ekman, Rolf and Wierup, Nils},
  issn         = {1873-5169},
  language     = {eng},
  pages        = {1109--1112},
  publisher    = {Elsevier},
  series       = {Peptides},
  title        = {Covariation of plasma ghrelin and motilin in irritable bowel syndrome.},
  url          = {http://dx.doi.org/10.1016/j.peptides.2010.03.021},
  volume       = {31},
  year         = {2010},
}