Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function Clinical recommendations
(2010) In Diabetes Care 33(6). p.1291-1293- Abstract
- AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual... (More)
- AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual overall coefficient of variation (CV) was 29.4 % (range 9,8-74,2). Conclusions: Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values over 20 mumol/L. Metformin measurement is less suitable for dose titration. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1582365
- author
- Frid, Anders LU ; Sterner, Gunnar LU ; Löndahl, Magnus LU ; Wiklander, Clara ; Cato, Anne ; Vinge, Ellen LU and Andersson, Anders S LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 33
- issue
- 6
- pages
- 1291 - 1293
- publisher
- American Diabetes Association
- external identifiers
-
- wos:000279304300027
- pmid:20215446
- scopus:77956065470
- pmid:20215446
- ISSN
- 1935-5548
- DOI
- 10.2337/dc09-1284
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Internal Medicine Research Unit (013242520), Medicine (Lund) (013230025), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- b1ad1da8-1375-4ae1-aa14-102b7698462e (old id 1582365)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20215446?dopt=Abstract
- date added to LUP
- 2016-04-01 10:35:35
- date last changed
- 2024-02-21 20:17:13
@article{b1ad1da8-1375-4ae1-aa14-102b7698462e,
abstract = {{AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual overall coefficient of variation (CV) was 29.4 % (range 9,8-74,2). Conclusions: Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values over 20 mumol/L. Metformin measurement is less suitable for dose titration.}},
author = {{Frid, Anders and Sterner, Gunnar and Löndahl, Magnus and Wiklander, Clara and Cato, Anne and Vinge, Ellen and Andersson, Anders S}},
issn = {{1935-5548}},
language = {{eng}},
number = {{6}},
pages = {{1291--1293}},
publisher = {{American Diabetes Association}},
series = {{Diabetes Care}},
title = {{Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function Clinical recommendations}},
url = {{http://dx.doi.org/10.2337/dc09-1284}},
doi = {{10.2337/dc09-1284}},
volume = {{33}},
year = {{2010}},
}