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Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function Clinical recommendations

Frid, Anders LU ; Sterner, Gunnar LU ; Löndahl, Magnus LU ; Wiklander, Clara; Cato, Anne; Vinge, Ellen LU and Andersson, Anders S LU (2010) In Diabetes Care 33(6). p.1291-1293
Abstract
AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual... (More)
AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual overall coefficient of variation (CV) was 29.4 % (range 9,8-74,2). Conclusions: Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values over 20 mumol/L. Metformin measurement is less suitable for dose titration. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
33
issue
6
pages
1291 - 1293
publisher
American Diabetes Association
external identifiers
  • wos:000279304300027
  • pmid:20215446
  • scopus:77956065470
ISSN
1935-5548
DOI
10.2337/dc09-1284
language
English
LU publication?
yes
id
b1ad1da8-1375-4ae1-aa14-102b7698462e (old id 1582365)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20215446?dopt=Abstract
date added to LUP
2010-04-07 14:36:47
date last changed
2018-06-10 03:20:37
@article{b1ad1da8-1375-4ae1-aa14-102b7698462e,
  abstract     = {AbstractObjective: To study trough levels of metformin in serum and its intra individual variation in patients using a newly developed assay. Research Design and Methods: Trough serum levels of metformin was measured once using Liquid Chromatography Tandem Mass Spectrometry (LcMSMS) in 137 type 2 diabetes patients with varying renal function (99 men) and followed repeatedly during two months in 20 patients (16 men) with estimated GFR (eGFR) below 60 ml/min/1.73 m(2) body surface. Results: Patients with eGFR &gt;60, 30-60, and &lt;30 ml/min/1.73 m(2) had a median trough metformin concentration of 4.5 mumol/l (range 0.1-20.7, n=107), 7.71 mumol/l (0.12-15.15, n=21), and 8.88 mumol/l (5.99-18.60, n=9), respectively. The median intraindividual overall coefficient of variation (CV) was 29.4 % (range 9,8-74,2). Conclusions: Determination of serum metformin with the LCMSMS technique is useful in patients on metformin treatment. Few patients had values over 20 mumol/L. Metformin measurement is less suitable for dose titration.},
  author       = {Frid, Anders and Sterner, Gunnar and Löndahl, Magnus and Wiklander, Clara and Cato, Anne and Vinge, Ellen and Andersson, Anders S},
  issn         = {1935-5548},
  language     = {eng},
  number       = {6},
  pages        = {1291--1293},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Novel Assay of Metformin Levels in Patients With Type 2 Diabetes and Varying Levels of Renal Function Clinical recommendations},
  url          = {http://dx.doi.org/10.2337/dc09-1284},
  volume       = {33},
  year         = {2010},
}