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Multibeam fluorescence diffuse optical tomography using upconverting nanoparticles.

Liu, Haichun LU ; Xu, Can LU and Andersson-Engels, Stefan LU (2010) In Optics Letters 35(5). p.718-720
Abstract
Fluorescence diffuse optical tomography (FDOT) is a biomedical imaging modality that can be used for localization and quantification of fluorescent molecules inside turbid media. In this ill-posed problem, the reconstruction quality is directly determined by the amount and quality of the information obtained from the boundary measurements. Regularly, more information can be obtained by increasing the number of excitation positions in an FDOT system. However, the maximum number of excitation positions is limited by the finite size of the excitation beam. In the present work, we demonstrate a method in FDOT to exploit the unique nonlinear power dependence of upconverting nanoparticles to further increase the amount of information in a... (More)
Fluorescence diffuse optical tomography (FDOT) is a biomedical imaging modality that can be used for localization and quantification of fluorescent molecules inside turbid media. In this ill-posed problem, the reconstruction quality is directly determined by the amount and quality of the information obtained from the boundary measurements. Regularly, more information can be obtained by increasing the number of excitation positions in an FDOT system. However, the maximum number of excitation positions is limited by the finite size of the excitation beam. In the present work, we demonstrate a method in FDOT to exploit the unique nonlinear power dependence of upconverting nanoparticles to further increase the amount of information in a raster-scanning setup by including excitation with two beams simultaneously. We show that the additional information can be used to obtain more accurate reconstructions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Letters
volume
35
issue
5
pages
718 - 720
publisher
Optical Society of America
external identifiers
  • wos:000275826700035
  • pmid:20195330
  • scopus:77649222419
ISSN
1539-4794
DOI
10.1364/OL.35.000718
language
English
LU publication?
yes
id
ce46fd00-cb1b-4654-a339-31027b3b697e (old id 1582638)
date added to LUP
2010-04-09 12:18:15
date last changed
2018-05-29 09:50:50
@article{ce46fd00-cb1b-4654-a339-31027b3b697e,
  abstract     = {Fluorescence diffuse optical tomography (FDOT) is a biomedical imaging modality that can be used for localization and quantification of fluorescent molecules inside turbid media. In this ill-posed problem, the reconstruction quality is directly determined by the amount and quality of the information obtained from the boundary measurements. Regularly, more information can be obtained by increasing the number of excitation positions in an FDOT system. However, the maximum number of excitation positions is limited by the finite size of the excitation beam. In the present work, we demonstrate a method in FDOT to exploit the unique nonlinear power dependence of upconverting nanoparticles to further increase the amount of information in a raster-scanning setup by including excitation with two beams simultaneously. We show that the additional information can be used to obtain more accurate reconstructions.},
  author       = {Liu, Haichun and Xu, Can and Andersson-Engels, Stefan},
  issn         = {1539-4794},
  language     = {eng},
  number       = {5},
  pages        = {718--720},
  publisher    = {Optical Society of America},
  series       = {Optics Letters},
  title        = {Multibeam fluorescence diffuse optical tomography using upconverting nanoparticles.},
  url          = {http://dx.doi.org/10.1364/OL.35.000718},
  volume       = {35},
  year         = {2010},
}