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Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice.

Alm, Ann-Sophie; Li, Ka; Chen, Hong; Wang, Diane; Andersson, Roland LU and Wang, Xiangdong LU (2010) In Respiratory Physiology & Neurobiology 171. p.157-164
Abstract
Clinical and experimental evidence suggests that genetic variations may play an important role in the development of acute lung injury (ALI). Lipopolysaccharide (LPS)-induced ALI models has been widely applied for pathophysiological and pharmacological research. In order to understand the variation of acute pulmonary reactions between mouse strains and find the optimal strain for target-oriented study, the present study investigated the alterations of acute lung hyperinflation, inflammation and injury in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J and C3H/HeN mice after the intra-tracheal challenge with LPS. We found that LPS-induced ALI varied between measured variables, durations and strains. General score of LPS-induced acute... (More)
Clinical and experimental evidence suggests that genetic variations may play an important role in the development of acute lung injury (ALI). Lipopolysaccharide (LPS)-induced ALI models has been widely applied for pathophysiological and pharmacological research. In order to understand the variation of acute pulmonary reactions between mouse strains and find the optimal strain for target-oriented study, the present study investigated the alterations of acute lung hyperinflation, inflammation and injury in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J and C3H/HeN mice after the intra-tracheal challenge with LPS. We found that LPS-induced ALI varied between measured variables, durations and strains. General score of LPS-induced acute lung hyperinflation, inflammation and edema followed the order CD-1, A/J, Balb/c, DBA/2J, C57BL/6J, DBA/1J, NMRI, C3H/HeN mice at 4h, and CD-1, C57BL/6J, Balb/c, C3H/HeN, NMRI, A/J, DBA/2J, DBA/1 mice at 24h. Thus, these data provide useful information to select sensitive or resistant strain mouse for understanding genetic variation of pathogenesis and screening of target-oriented drugs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Physiology & Neurobiology
volume
171
pages
157 - 164
publisher
Elsevier
external identifiers
  • wos:000278630700014
  • pmid:20188866
  • scopus:77950988936
ISSN
1878-1519
DOI
10.1016/j.resp.2010.02.009
language
English
LU publication?
yes
id
d53ca554-7b58-462a-ab2c-7d62e524a5aa (old id 1582777)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20188866?dopt=Abstract
date added to LUP
2010-04-07 09:30:04
date last changed
2018-05-29 10:28:30
@article{d53ca554-7b58-462a-ab2c-7d62e524a5aa,
  abstract     = {Clinical and experimental evidence suggests that genetic variations may play an important role in the development of acute lung injury (ALI). Lipopolysaccharide (LPS)-induced ALI models has been widely applied for pathophysiological and pharmacological research. In order to understand the variation of acute pulmonary reactions between mouse strains and find the optimal strain for target-oriented study, the present study investigated the alterations of acute lung hyperinflation, inflammation and injury in C57BL/6J, Balb/cJ, DBA/1J, CD-1, NMRI, DBA/2J, A/J and C3H/HeN mice after the intra-tracheal challenge with LPS. We found that LPS-induced ALI varied between measured variables, durations and strains. General score of LPS-induced acute lung hyperinflation, inflammation and edema followed the order CD-1, A/J, Balb/c, DBA/2J, C57BL/6J, DBA/1J, NMRI, C3H/HeN mice at 4h, and CD-1, C57BL/6J, Balb/c, C3H/HeN, NMRI, A/J, DBA/2J, DBA/1 mice at 24h. Thus, these data provide useful information to select sensitive or resistant strain mouse for understanding genetic variation of pathogenesis and screening of target-oriented drugs.},
  author       = {Alm, Ann-Sophie and Li, Ka and Chen, Hong and Wang, Diane and Andersson, Roland and Wang, Xiangdong},
  issn         = {1878-1519},
  language     = {eng},
  pages        = {157--164},
  publisher    = {Elsevier},
  series       = {Respiratory Physiology & Neurobiology},
  title        = {Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice.},
  url          = {http://dx.doi.org/10.1016/j.resp.2010.02.009},
  volume       = {171},
  year         = {2010},
}