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Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies.

Källén, Bengt LU ; Finnström, O; Lindam, A; Nilsson, E; Nygren, K-G and Olausson, P Otterblad (2010) In BJOG : an international journal of obstetrics and gynaecology Apr 7. p.676-682
Abstract
Please cite this paper as: Källén B, Finnström O, Lindam A, Nilsson E, Nygren K-G, Otterblad Olausson P. Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies. BJOG 2010; Objective To compare neonatal outcome among twins conceived after in vitro fertilisation (IVF) with that of spontaneously conceived twins. Design Comparison of different-sex (dizygotic) twins born after IVF with non-IVF dizygotic twins. Setting National health registers in Sweden. Population All births in Sweden during the period 1982-2007. Methods We studied gestational duration, lowest birthweight and birthweight difference in the twin pair, presence of one or two twins with a respiratory complication, and with jaundice in one or both twins.... (More)
Please cite this paper as: Källén B, Finnström O, Lindam A, Nilsson E, Nygren K-G, Otterblad Olausson P. Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies. BJOG 2010; Objective To compare neonatal outcome among twins conceived after in vitro fertilisation (IVF) with that of spontaneously conceived twins. Design Comparison of different-sex (dizygotic) twins born after IVF with non-IVF dizygotic twins. Setting National health registers in Sweden. Population All births in Sweden during the period 1982-2007. Methods We studied gestational duration, lowest birthweight and birthweight difference in the twin pair, presence of one or two twins with a respiratory complication, and with jaundice in one or both twins. Risk estimates were calculated as odds ratios with adjustments for year of birth, maternal age, parity and smoking in pregnancy. Main outcome measures Gestational duration, birth weight, respiratory complications, jaundice. Results We studied 1545 pairs of dizygotic twins born after IVF, and 8675 pairs of dizygotic twins where IVF was not known to have occurred. The risk for preterm delivery before 32 weeks of gestation was significantly increased among dizygotic twin pairs born after IVF compared with non-IVF dizygotic twin pairs. No significant difference in low birthweight or birthweight difference within twin pairs was seen. There was an increased occurrence of twin pairs with respiratory problems or jaundice, but only the latter diagnosis occurred in a statistically significant excess. Conclusions The study confirms recent findings that IVF is associated with an increased risk for some neonatal complications, not only among singletons but also among twins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BJOG : an international journal of obstetrics and gynaecology
volume
Apr 7
pages
676 - 682
publisher
Wiley-Blackwell
external identifiers
  • WOS:000276509100005
  • PMID:20184569
  • Scopus:77950630680
ISSN
1471-0528
DOI
10.1111/j.1471-0528.2010.02517.x
language
English
LU publication?
yes
id
55d06093-d811-45d8-a356-790246dc27f6 (old id 1582871)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20184569?dopt=Abstract
date added to LUP
2010-04-07 10:28:01
date last changed
2017-01-01 07:53:20
@article{55d06093-d811-45d8-a356-790246dc27f6,
  abstract     = {Please cite this paper as: Källén B, Finnström O, Lindam A, Nilsson E, Nygren K-G, Otterblad Olausson P. Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies. BJOG 2010; Objective To compare neonatal outcome among twins conceived after in vitro fertilisation (IVF) with that of spontaneously conceived twins. Design Comparison of different-sex (dizygotic) twins born after IVF with non-IVF dizygotic twins. Setting National health registers in Sweden. Population All births in Sweden during the period 1982-2007. Methods We studied gestational duration, lowest birthweight and birthweight difference in the twin pair, presence of one or two twins with a respiratory complication, and with jaundice in one or both twins. Risk estimates were calculated as odds ratios with adjustments for year of birth, maternal age, parity and smoking in pregnancy. Main outcome measures Gestational duration, birth weight, respiratory complications, jaundice. Results We studied 1545 pairs of dizygotic twins born after IVF, and 8675 pairs of dizygotic twins where IVF was not known to have occurred. The risk for preterm delivery before 32 weeks of gestation was significantly increased among dizygotic twin pairs born after IVF compared with non-IVF dizygotic twin pairs. No significant difference in low birthweight or birthweight difference within twin pairs was seen. There was an increased occurrence of twin pairs with respiratory problems or jaundice, but only the latter diagnosis occurred in a statistically significant excess. Conclusions The study confirms recent findings that IVF is associated with an increased risk for some neonatal complications, not only among singletons but also among twins.},
  author       = {Källén, Bengt and Finnström, O and Lindam, A and Nilsson, E and Nygren, K-G and Olausson, P Otterblad},
  issn         = {1471-0528},
  language     = {eng},
  pages        = {676--682},
  publisher    = {Wiley-Blackwell},
  series       = {BJOG : an international journal of obstetrics and gynaecology},
  title        = {Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies.},
  url          = {http://dx.doi.org/10.1111/j.1471-0528.2010.02517.x},
  volume       = {Apr 7},
  year         = {2010},
}