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Glioma stem cells: Evidence and limitation.

Fan, Xiaolong LU ; Salford, Leif LU and Widegren, Bengt LU (2007) In Seminars in Cancer Biology 17(3). p.214-218
Abstract
Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manifested by morphological, genetic and phenotypic heterogeneity. Most of the studies hitherto have been performed on bulk glioma cells, with limited understanding on the origin and the relative contribution of particular glioma cell populations to glioma growth and progression. Recent studies have demonstrated the existence of a small fraction of glioma cells endowed with features of primitive neural progenitor cells and tumor-initiating function. Such cells have been defined as glioma stem cells. However, questions remain as to whether the currently identified glioma stem cells are the cell-of-origin for glioma initiation and progression, or... (More)
Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manifested by morphological, genetic and phenotypic heterogeneity. Most of the studies hitherto have been performed on bulk glioma cells, with limited understanding on the origin and the relative contribution of particular glioma cell populations to glioma growth and progression. Recent studies have demonstrated the existence of a small fraction of glioma cells endowed with features of primitive neural progenitor cells and tumor-initiating function. Such cells have been defined as glioma stem cells. However, questions remain as to whether the currently identified glioma stem cells are the cell-of-origin for glioma initiation and progression, or the results of such processes. In this review, we discuss the current evidence and limitation in identifying glioma stem cells and the potential origin of glioma stem cells in the context of post-natal neural cell regeneration and their transformation mechanisms. The implication of these findings for glioma diagnosis and treatment will also be reviewed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Cancer Biology
volume
17
issue
3
pages
214 - 218
publisher
Academic Press
external identifiers
  • wos:000246860300004
  • scopus:33947143429
ISSN
1096-3650
DOI
10.1016/j.semcancer.2006.04.002
language
English
LU publication?
yes
id
d246e6af-fe40-4746-aff9-b3bf35b681bd (old id 158497)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16750389&dopt=Abstract
date added to LUP
2007-07-11 09:58:30
date last changed
2017-09-24 04:20:37
@article{d246e6af-fe40-4746-aff9-b3bf35b681bd,
  abstract     = {Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manifested by morphological, genetic and phenotypic heterogeneity. Most of the studies hitherto have been performed on bulk glioma cells, with limited understanding on the origin and the relative contribution of particular glioma cell populations to glioma growth and progression. Recent studies have demonstrated the existence of a small fraction of glioma cells endowed with features of primitive neural progenitor cells and tumor-initiating function. Such cells have been defined as glioma stem cells. However, questions remain as to whether the currently identified glioma stem cells are the cell-of-origin for glioma initiation and progression, or the results of such processes. In this review, we discuss the current evidence and limitation in identifying glioma stem cells and the potential origin of glioma stem cells in the context of post-natal neural cell regeneration and their transformation mechanisms. The implication of these findings for glioma diagnosis and treatment will also be reviewed.},
  author       = {Fan, Xiaolong and Salford, Leif and Widegren, Bengt},
  issn         = {1096-3650},
  language     = {eng},
  number       = {3},
  pages        = {214--218},
  publisher    = {Academic Press},
  series       = {Seminars in Cancer Biology},
  title        = {Glioma stem cells: Evidence and limitation.},
  url          = {http://dx.doi.org/10.1016/j.semcancer.2006.04.002},
  volume       = {17},
  year         = {2007},
}