Glioma stem cells: Evidence and limitation.
(2007) In Seminars in Cancer Biology 17(3). p.214-218- Abstract
- Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manifested by morphological, genetic and phenotypic heterogeneity. Most of the studies hitherto have been performed on bulk glioma cells, with limited understanding on the origin and the relative contribution of particular glioma cell populations to glioma growth and progression. Recent studies have demonstrated the existence of a small fraction of glioma cells endowed with features of primitive neural progenitor cells and tumor-initiating function. Such cells have been defined as glioma stem cells. However, questions remain as to whether the currently identified glioma stem cells are the cell-of-origin for glioma initiation and progression, or... (More)
- Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manifested by morphological, genetic and phenotypic heterogeneity. Most of the studies hitherto have been performed on bulk glioma cells, with limited understanding on the origin and the relative contribution of particular glioma cell populations to glioma growth and progression. Recent studies have demonstrated the existence of a small fraction of glioma cells endowed with features of primitive neural progenitor cells and tumor-initiating function. Such cells have been defined as glioma stem cells. However, questions remain as to whether the currently identified glioma stem cells are the cell-of-origin for glioma initiation and progression, or the results of such processes. In this review, we discuss the current evidence and limitation in identifying glioma stem cells and the potential origin of glioma stem cells in the context of post-natal neural cell regeneration and their transformation mechanisms. The implication of these findings for glioma diagnosis and treatment will also be reviewed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/158497
- author
- Fan, Xiaolong LU ; Salford, Leif LU and Widegren, Bengt LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Seminars in Cancer Biology
- volume
- 17
- issue
- 3
- pages
- 214 - 218
- publisher
- Academic Press
- external identifiers
-
- wos:000246860300004
- scopus:33947143429
- ISSN
- 1096-3650
- DOI
- 10.1016/j.semcancer.2006.04.002
- language
- English
- LU publication?
- yes
- id
- d246e6af-fe40-4746-aff9-b3bf35b681bd (old id 158497)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16750389&dopt=Abstract
- date added to LUP
- 2016-04-01 15:49:08
- date last changed
- 2022-01-28 07:16:56
@article{d246e6af-fe40-4746-aff9-b3bf35b681bd,
abstract = {{Gliomas, in particular the high-grade anaplastic glioma and glioblastoma multiforme (GBM), are manifested by morphological, genetic and phenotypic heterogeneity. Most of the studies hitherto have been performed on bulk glioma cells, with limited understanding on the origin and the relative contribution of particular glioma cell populations to glioma growth and progression. Recent studies have demonstrated the existence of a small fraction of glioma cells endowed with features of primitive neural progenitor cells and tumor-initiating function. Such cells have been defined as glioma stem cells. However, questions remain as to whether the currently identified glioma stem cells are the cell-of-origin for glioma initiation and progression, or the results of such processes. In this review, we discuss the current evidence and limitation in identifying glioma stem cells and the potential origin of glioma stem cells in the context of post-natal neural cell regeneration and their transformation mechanisms. The implication of these findings for glioma diagnosis and treatment will also be reviewed.}},
author = {{Fan, Xiaolong and Salford, Leif and Widegren, Bengt}},
issn = {{1096-3650}},
language = {{eng}},
number = {{3}},
pages = {{214--218}},
publisher = {{Academic Press}},
series = {{Seminars in Cancer Biology}},
title = {{Glioma stem cells: Evidence and limitation.}},
url = {{http://dx.doi.org/10.1016/j.semcancer.2006.04.002}},
doi = {{10.1016/j.semcancer.2006.04.002}},
volume = {{17}},
year = {{2007}},
}