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Regional variations of vasomotion to G-protein coupled receptor agonists following heat stress in rats

Li, Jie; Cao, Yong-Xiao; Chen, Kun-Lun; Cao, Lei; Ma, Zhao and Xu, Cang-Bao LU (2010) In Journal of Pharmacy and Pharmacology 62(3). p.315-322
Abstract
Objectives This study was designed to compare vascular contractile and relaxing responses to G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. Methods Heat exposure was performed by increasing the internal temperature of the rats to 42 degrees C for 15 min. After heat stress for 48 h, a rnyograph system was used to monitor the contractile responses in rat renal, femoral and mesenteric arteries to agonists of endothelin type B (ETB) receptor, endothelin type A (ETA) receptor, serotonin receptor and alpha-adrenoceptor, respectively. In addition, calcitonin gene-related peptide (CGRP)-induced vasodilation was studied. Key findings The results showed that heat stress induced decreased... (More)
Objectives This study was designed to compare vascular contractile and relaxing responses to G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. Methods Heat exposure was performed by increasing the internal temperature of the rats to 42 degrees C for 15 min. After heat stress for 48 h, a rnyograph system was used to monitor the contractile responses in rat renal, femoral and mesenteric arteries to agonists of endothelin type B (ETB) receptor, endothelin type A (ETA) receptor, serotonin receptor and alpha-adrenoceptor, respectively. In addition, calcitonin gene-related peptide (CGRP)-induced vasodilation was studied. Key findings The results showed that heat stress induced decreased contractions mediated by alpha-adrenoceptors and serotonin receptors (at lower concentration), while it increased contraction mediated by endothelin ETB receptors and enhanced relaxation mediated by CGRP receptors in the renal artery. Heat stress increased contractions mediated by endothelin ETB receptors, endothelin ETA receptors and alpha-adrenoceptors in the femoral artery. In the mesenteric artery, heat stress increased contractions mediated by endothelin ETB and serotonin receptors and relaxation mediated by CGRP receptors. Conclusions The vasomotor responses to the G-protein coupled receptor agonists with altered vascular contractions and relaxations were different in rat renal, femoral and mesenteric arteries after heat stress. This might have contributed to the redistribution of blood flow and aids understanding of the preconditioning phenomenon. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
heat stress rat, artery, G-protein coupled receptor, vasomotion
in
Journal of Pharmacy and Pharmacology
volume
62
issue
3
pages
315 - 322
publisher
Pharmaceutical Press
external identifiers
  • wos:000276259300005
  • scopus:77950245009
ISSN
0022-3573
DOI
10.1211/jpp/62.03.0005
language
English
LU publication?
yes
id
98e09047-a9d9-4d6e-afaf-648a2824a057 (old id 1586988)
date added to LUP
2010-04-27 10:42:18
date last changed
2018-05-29 11:12:05
@article{98e09047-a9d9-4d6e-afaf-648a2824a057,
  abstract     = {Objectives This study was designed to compare vascular contractile and relaxing responses to G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. Methods Heat exposure was performed by increasing the internal temperature of the rats to 42 degrees C for 15 min. After heat stress for 48 h, a rnyograph system was used to monitor the contractile responses in rat renal, femoral and mesenteric arteries to agonists of endothelin type B (ETB) receptor, endothelin type A (ETA) receptor, serotonin receptor and alpha-adrenoceptor, respectively. In addition, calcitonin gene-related peptide (CGRP)-induced vasodilation was studied. Key findings The results showed that heat stress induced decreased contractions mediated by alpha-adrenoceptors and serotonin receptors (at lower concentration), while it increased contraction mediated by endothelin ETB receptors and enhanced relaxation mediated by CGRP receptors in the renal artery. Heat stress increased contractions mediated by endothelin ETB receptors, endothelin ETA receptors and alpha-adrenoceptors in the femoral artery. In the mesenteric artery, heat stress increased contractions mediated by endothelin ETB and serotonin receptors and relaxation mediated by CGRP receptors. Conclusions The vasomotor responses to the G-protein coupled receptor agonists with altered vascular contractions and relaxations were different in rat renal, femoral and mesenteric arteries after heat stress. This might have contributed to the redistribution of blood flow and aids understanding of the preconditioning phenomenon.},
  author       = {Li, Jie and Cao, Yong-Xiao and Chen, Kun-Lun and Cao, Lei and Ma, Zhao and Xu, Cang-Bao},
  issn         = {0022-3573},
  keyword      = {heat stress rat,artery,G-protein coupled receptor,vasomotion},
  language     = {eng},
  number       = {3},
  pages        = {315--322},
  publisher    = {Pharmaceutical Press},
  series       = {Journal of Pharmacy and Pharmacology},
  title        = {Regional variations of vasomotion to G-protein coupled receptor agonists following heat stress in rats},
  url          = {http://dx.doi.org/10.1211/jpp/62.03.0005},
  volume       = {62},
  year         = {2010},
}